Genetics and Evolution of Aging

1. Front Matter

   Pages I-2

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2. General perspectives on aging

   1. Front Matter

      Pages 3-4

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   2. The Janiform genetics of aging

      • Michael R. Rose, Caleb E. Finch

      Pages 5-12

   3. Evolutionary mechanisms of senescence

      • Brian Charlesworth

      Pages 13-21

   4. Mutation-selection balance and the evolution of senescence

      • Andrew G. Clark

      Pages 22-28

   5. Pathogen evolution within host individuals as a primary cause of senescence

      • Graham Bell

      Pages 29-42

3. Diversity of aging

   1. Front Matter

      Pages 43-44

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   2. Comparative approaches to the study of senescence: bridging genetics and phylogenetics

      • Daniel E. L. Promislow, Marc Tatar

      Pages 45-53

   3. The genetics of aging in the yeast Saccharomyces cerevisiae

      • S. Michal Jazwinski

      Pages 54-70

   4. Evolutionary senescence in plants

      • Deborah Ann Roach

      Pages 71-82

   5. Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans

      • Thomas E. Johnson, Patricia M. Tedesco, Gordon J. Lithgow

      Pages 83-95

   6. New model systems for studying the evolutionary biology of aging: crustacea

      • David Reznick

      Pages 96-105

4. Aging in Drosophila

   1. Front Matter

      Pages 107-108

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   2. Evolution of aging: testing the theory using Drosophila

      • L. Partridge, N. H. Barton

      Pages 109-118

   3. Population density effects on longevity

      • Joseph L. Graves Jr., Laurence D. Mueller

      Pages 119-129

   4. Evolution of delayed reproductive senescence in male fruit flies: sperm competition

      • Philip M. Service, Amanda J. Fales

      Pages 130-144

   5. Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain of Drosophila

      • Robert Arking, Steven P. Dudas, George T. Baker III

      Pages 145-160

   6. The effect of superoxide dismutase alleles on aging in Drosophila

      • Robert H. Tyler, Hardip Brar, Meena Singh, Amparo Latorre, Joseph L. Graves, Laurence D. Mueller et al.

      Pages 161-167

   7. Use of recombinant inbred strains to map genes of aging

      • Linda K. Dixon

      Pages 168-182

   8. The effects of enhanced expression of elongation factor EF-1α on lifespan in Drosophila melanogaster

      • Stephen C. Stearns, Marcel Kaiser

      Pages 183-198

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population­ genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host­ pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

• Allele
• Elongation
• Mutation
• evolution
• evolutionary biology
• genes
• genetics
• molecular biology
• mutant
• saccharomyces cerevisiae

• University of California, Irvine, USA

  Michael R. Rose

• University of Southern California, Los Angeles, USA

  Caleb E. Finch

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