Developments in Nuclear Medicine

Radioiodination: Theory, Practice, and Biomedical Applications

Authors: Dewanjee, Mrinal K.

Buy this book

eBook $429.00 net
( price for USA )
  • ISBN 978-1-4615-3508-9
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Hardcover $539.00 net
( price for USA )
  • ISBN 978-0-7923-1491-2
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days
Softcover $539.00 net
( price for USA )
  • ISBN 978-1-4613-6556-3
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days
About this book

Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

Table of contents (3 chapter)

  • Production of 131I, 125I, and 123I Radionuclides and their Separation from Targets

    Mrinal K. Dewanjee Ph.D.

    Pages 47-65

    Buy Chapter $29.95
  • Chemistry of Radioiodination Reactions

    Mrinal K. Dewanjee Ph.D.

    Pages 69-125

    Buy Chapter $29.95
  • Miscellaneous Radioiodinated Polymers and Beads

    Mrinal K. Dewanjee Ph.D.

    Pages 533-536

    Buy Chapter $29.95
Free Preview

Buy this book

eBook $429.00 net
( price for USA )
  • ISBN 978-1-4615-3508-9
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Hardcover $539.00 net
( price for USA )
  • ISBN 978-0-7923-1491-2
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days
Softcover $539.00 net
( price for USA )
  • ISBN 978-1-4613-6556-3
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Radioiodination: Theory, Practice, and Biomedical Applications
Series Title
Developments in Nuclear Medicine
Series Volume
21
Copyright
1992
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4615-3508-9
DOI
10.1007/978-1-4615-3508-9
Hardcover ISBN
978-0-7923-1491-2
Softcover ISBN
978-1-4613-6556-3
Edition Number
1
Topics