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Radioiodination: Theory, Practice, and Biomedical Applications

  • Book
  • © 1992

Overview

Authors:
  1. Mrinal K. Dewanjee

    1. Radiopharmaceutical Laboratory, USA
      Jackson Memorial Medical Center and University of Miami Hospital and Clinics, USA
      Surgery and Biomedical Engineering, University of Miami School of Medicine, USA

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    You can also search for this author in PubMed   Google Scholar

Part of the book series: Developments in Nuclear Medicine (DNUM, volume 21)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-1
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  3. Preparation of Tracers

    1. Front Matter

      Pages 67-67
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    2. Chemistry of Radioiodination Reactions

      • Mrinal K. Dewanjee
      Pages 69-125

  4. Localization of Tracers

    1. Front Matter

      Pages 127-127
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    2. Methods of Radioiodination Reactions with Several Oxidizing Agents

      • Mrinal K. Dewanjee
      Pages 129-218

    3. Mechanisms of Tracer Localization

      • Mrinal K. Dewanjee
      Pages 219-229

  5. Organ Imaging and Tracer Applications

    1. Front Matter

      Pages 231-231
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    2. Radioiodinated Small Molecules and Their Applications

      • Mrinal K. Dewanjee
      Pages 233-387

    3. Radioiodinated Macromolecules

      • Mrinal K. Dewanjee
      Pages 389-411

    4. Applications of Radioiodinated Macromolecules

      • Mrinal K. Dewanjee
      Pages 413-512

    5. Radioiodinated Lipoproteins

      • Mrinal K. Dewanjee
      Pages 513-522

    6. Radioiodinated Peptides and Growth Factors and Their Applications

      • Mrinal K. Dewanjee
      Pages 523-531

    7. Miscellaneous Radioiodinated Polymers and Beads

      • Mrinal K. Dewanjee
      Pages 533-536
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Keywords

About this book

Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

Authors and Affiliations

  • Radiopharmaceutical Laboratory, USA

    Mrinal K. Dewanjee

  • Jackson Memorial Medical Center and University of Miami Hospital and Clinics, USA

    Mrinal K. Dewanjee

  • Surgery and Biomedical Engineering, University of Miami School of Medicine, USA

    Mrinal K. Dewanjee

Bibliographic Information

  • Book Title: Radioiodination: Theory, Practice, and Biomedical Applications

  • Authors: Mrinal K. Dewanjee

  • Series Title: Developments in Nuclear Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-3508-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-7923-1491-2Published: 31 January 1992

  • Softcover ISBN: 978-1-4613-6556-3Published: 03 October 2012

  • eBook ISBN: 978-1-4615-3508-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIII, 621

  • Topics: Nuclear Medicine, Diagnostic Radiology, Imaging / Radiology

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