Cancer Treatment and Research

Regulatory Mechanisms in Breast Cancer

Advances in Cellular and Molecular Biology of Breast Cancer

Editors: Lippman, Marc E., Dickson, Robert B. (Eds.)

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eBook $329.00
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  • ISBN 978-1-4615-3940-7
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Hardcover $419.00
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  • ISBN 978-0-7923-0868-3
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Softcover $419.00
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  • ISBN 978-1-4613-6758-1
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About this book

In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub­ lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres­ sion. In the two years since its publication, much new and exciting in­ formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho­ logists to establish prognostic outcome. Of particular interest is a new proto­ oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas­ toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto­ oncogene and antioncogene expression.

Reviews

This book is excellent in overall quality. The book is an important and useful addition to the scientific literature. It provides a fresh perspective on breast cancer for students and for clinical and basic researchers alike.Journal of the Nat. Cancer

Table of contents (20 chapters)

  • Oncogenes as clinical prognostic indicators

    Sunderland, Margaret C. (et al.)

    Pages 3-22

  • Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma

    Lee, Eva Y.-H. P. (et al.)

    Pages 23-44

  • Relationship of growth factors and differentiation in normal and neoplastic development of the mammary gland

    Fernig, David G. (et al.)

    Pages 47-78

  • Local effects of growth factors

    Daniel, Charles W. (et al.)

    Pages 79-92

  • The insulin-like growth factors, their receptors, and their binding proteins in human breast cancer

    Yee, Douglas (et al.)

    Pages 93-106

Buy this book

eBook $329.00
price for USA (gross)
  • ISBN 978-1-4615-3940-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $419.00
price for USA
  • ISBN 978-0-7923-0868-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $419.00
price for USA
  • ISBN 978-1-4613-6758-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Regulatory Mechanisms in Breast Cancer
Book Subtitle
Advances in Cellular and Molecular Biology of Breast Cancer
Editors
  • Marc E. Lippman
  • Robert B. Dickson
Series Title
Cancer Treatment and Research
Series Volume
53
Copyright
1991
Publisher
Springer US
Copyright Holder
Kluwer Academic Publishers
eBook ISBN
978-1-4615-3940-7
DOI
10.1007/978-1-4615-3940-7
Hardcover ISBN
978-0-7923-0868-3
Softcover ISBN
978-1-4613-6758-1
Series ISSN
0927-3042
Edition Number
1
Number of Pages
IV, 452
Topics