Biological and Medical Physics, Biomedical Engineering

Biophysics of DNA-Protein Interactions

From Single Molecules to Biological Systems

Editors: Williams, Mark C., Maher, III, L. James (Eds.)

  • Covers expert perspectives on a wide array of important DNA-protein interactions from physical perspective
  • Outlines recent accomplishments in the rapidly expanding area of biophysics
  • Provides information for anyone studying DNA interactions at all biological levels
  • Relevant to people working in molecular biology, biochemisty, and biophysics
  • Includes new single molecule and bulk methods that shed light on biological problems
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  • ISBN 978-0-387-92808-1
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Hardcover $169.00
price for USA
  • ISBN 978-0-387-92807-4
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  • ISBN 978-1-4614-2695-0
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About this book

This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by which proteins search for and recognize specific binding sites on DNA, a process critical for cellular function. Single molecule methods such as force spectroscopy as well as fluorescence imaging and tracking are described in these chapters as well as other parts of the book that address the dynamics of protein-DNA interactions. Other important topics include the mechanisms by which proteins engage DNA sequences and/or alter DNA structure. These simple but important model interactions are then placed in the broader biological context with discussion of larger protein-DNA complexes . Topics include replication forks, recombination complexes, DNA repair interactions, and ultimately, methods to understand the chromatin context of the cell nucleus. This book will be of interest to readers who wish to explore current biophysical approaches to DNA-protein interactions across multiple levels of biological complexity.

Table of contents (14 chapters)

  • Introduction to Biophysics of DNA–Protein Interactions: From Single Molecules to Biological Systems

    Williams, Mark C. (et al.)

    Pages 3-8

  • Single-Molecule Imaging of LacI Diffusing Along Nonspecific DNA

    Wang, Y. M. (et al.)

    Pages 9-38

  • How Proteins Slide on DNA

    Barsky, Daniel (et al.)

    Pages 39-68

  • Role of DNA Conformations in Gene Regulation

    Metzler, Ralf (et al.)

    Pages 69-84

  • Recognition of Nucleic Acids by Transcription Factor NF-κB

    Ghosh, Gourisankar (et al.)

    Pages 85-106

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-0-387-92808-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.00
price for USA
  • ISBN 978-0-387-92807-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.00
price for USA
  • ISBN 978-1-4614-2695-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Biophysics of DNA-Protein Interactions
Book Subtitle
From Single Molecules to Biological Systems
Editors
  • Mark C. Williams
  • L. James Maher, III
Series Title
Biological and Medical Physics, Biomedical Engineering
Copyright
2011
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media, LLC
eBook ISBN
978-0-387-92808-1
DOI
10.1007/978-0-387-92808-1
Hardcover ISBN
978-0-387-92807-4
Softcover ISBN
978-1-4614-2695-0
Series ISSN
1618-7210
Edition Number
1
Number of Pages
X, 350
Topics