The Sticky Synapse

Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance

Editors: Hortsch, Michael, Umemori, Hisashi (Eds.)

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About this book

Over the last few years, a considerable number of different cell adhesion molecules (CAMs) have been identified that are imperative for synapse formation and maintenance. Recent research, however, has also revealed that many synaptic connections are highly dynamic and not as stable as initially thought. A delicate balance between adhesive and anti-adhesive events at the synapse suggests that CAM functions are highly regulated. Dr. Michael Hortsch and Dr. Hisashi Umemori's The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance presents the first comprehensive synopsis on how adhesive proteins contribute to synapse formation, function, and remodeling. Topics discussed range from general synaptic processes, such as neuromuscular junction and CNS synapse formation, to CAM-specific chapters on Cadherins, Ig-domain CAMs, Neuroligins, extracellular matrix molecules, Connexins and many others, and how these CAM families contribute specifically to synaptic functionality. The wide range of general and technical information offered in this book will appeal to students, researchers, and clinicians in the fields of molecular and cellular neuroscience, neurophysiology, and developmental neurobiology.

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About the editors:

Dr. Michael Hortsch holds a Diploma degree in Biochemistry from the Free University Berlin and a Ph.D. in Biology from the University of Heidelberg in Germany.While working at theWeizmann Institute in Israel, the European Molecular Biology Laboratory in Heidelberg, and at the University of California at Berkeley he has published on topics such as the mechanism of growth factor receptor activation, the transport of proteins across membranes, and the physiological roles of neuronal cell adhesion molecules during nervous system development. He has been a faculty member of the Department of Cell and Developmental Biology at the University of Michigan in Ann Arbor since 1991. Dr. Hortsch has served on scientific review panels for the National Institutes of Health, the National Science Foundation, and other agencies.

Dr. Hisashi Umemori is a faculty member of the Molecular and Behavioral Neuroscience Institute and of the Department of Biological Chemistry at the University of Michigan Medical School. He worked with Dr. Tadashi Yamamoto at the Institute of Medical Sciences of the University of Tokyo and analyzed intracellular signaling mechanisms that are involved in myelination and in learning and memory.While working with Dr. Joshua R. Sanes atWashington University Medical School and at Harvard University, he identified synaptic organizing molecules that promote synapse formation during nervous system development. Currently, his laboratory is working to uncover the molecular mechanisms that govern the formation of functional neural circuits in the brain. Dr. Umemori has received various awards, including a Basil O'Connor Award and a Klingenstein Fellowship Award.

 

 

 

About the authors

Dr. Michael Hortsch holds a Diploma degree in Biochemistry from the Free University Berlin and a Ph.D. in Biology from the University of Heidelberg in Germany. While working at the Weizmann Institute in Israel, the European Molecular Biology Laboratory in Heidelberg, and at the University of California at Berkeley he has published on topics such as the mechanism of growth factor receptor activation, the transport of proteins across membranes, and the physiological roles of neuronal cell adhesion molecules during nervous system development. He has been a faculty member of the Department of Cell and Developmental Biology at the University of Michigan in Ann Arbor since 1991. Dr. Hortsch has served on scientific review panels for the National Institutes of Health, the National Science Foundation, and other agencies.

 

Dr. Hisashi Umemori is a faculty member of the Molecular and Behavioral Neuroscience Institute and of the Department of Biological Chemistry at the University of Michigan Medical School. He worked with Dr. Tadashi Yamamoto at the Institute of Medical Sciences of the University of Tokyo and analyzed intracellular signaling mechanisms that are involved in myelination and in learning and memory. While working with Dr. Joshua R. Sanes at Washington University Medical School and at Harvard University, he identified synaptic organizing molecules that promote synapse formation during nervous system development. Dr. Umemori has received various awards, including a Basil O'Connor Award and a Klingenstein Fellowship Award.

 

 

Table of contents (21 chapters)

  • A Short History of the Synapse – Golgi Versus Ramón y Cajal

    Hortsch, Michael

    Pages 1-9

  • Cell Adhesion Molecules at the Drosophila Neuromuscular Junction

    Carrero-Martínez, Franklin A. (et al.)

    Pages 11-37

  • Development of the Vertebrate Neuromuscular Junction

    Fox, Michael A.

    Pages 39-84

  • Synapse Formation in the Mammalian Central Nervous System

    Yasuda, Masahiro (et al.)

    Pages 85-106

  • Developmental Axonal Pruning and Synaptic Plasticity

    Scelfo, Bibiana (et al.)

    Pages 107-140

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-0-387-92708-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-387-92707-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4899-8289-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Sticky Synapse
Book Subtitle
Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance
Editors
  • Michael Hortsch
  • Hisashi Umemori
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-92708-4
DOI
10.1007/978-0-387-92708-4
Hardcover ISBN
978-0-387-92707-7
Softcover ISBN
978-1-4899-8289-6
Edition Number
1
Number of Pages
XII, 453
Topics