Springer Series in Computational Neuroscience

Dynamic-Clamp

From Principles to Applications

Editors: Destexhe, Alain, Bal, Thierry (Eds.)

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-0-387-89279-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-0-387-89278-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-2790-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called "conductance injection") allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer.

The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic- Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons.

This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.

About the Editors:

Dr. Alain Destexhe and Dr. Thierry Bal are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the UNIC (Unité de Neurosciences Intégratives et Computationnelles) research unit. This campus is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Dr. Bal and Dr. Destexhe. Each editor holds Ph.D.s in biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.

About the authors

Dr. Alain Destexhe and Dr.Thierry Bal, are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Bal and Destexhe. Each editor holds Ph.D.s in both biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.

Table of contents (18 chapters)

  • Development of a Genetically Engineered Cardiac Pacemaker: Insights from Dynamic Action Potential Clamp Experiments

    Verkerk, Arie O. (et al.)

    Pages 1-17

  • Associating Living Cells and Computational Models: an Introduction to Dynamic Clamp Principles and its Applications

    Piwkowska, Zuzanna (et al.)

    Pages 1-30

  • Dendritic Dynamic Clamp – A Tool to Study Single Neuron Computation

    Williams, Stephen R.

    Pages 31-47

  • Synaptic Conductances and Spike Generation in Cortical Cells

    Robinson, Hugh P. C.

    Pages 49-71

  • Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp

    Chance, Frances (et al.)

    Pages 73-87

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-0-387-89279-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-0-387-89278-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-2790-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Dynamic-Clamp
Book Subtitle
From Principles to Applications
Editors
  • Alain Destexhe
  • Thierry Bal
Series Title
Springer Series in Computational Neuroscience
Series Volume
1
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-89279-5
DOI
10.1007/978-0-387-89279-5
Hardcover ISBN
978-0-387-89278-8
Softcover ISBN
978-1-4419-2790-3
Series ISSN
2197-1900
Edition Number
1
Number of Pages
XIV, 429
Number of Illustrations and Tables
60 b/w illustrations
Topics