Advances in Experimental Medicine and Biology

Tropomyosin

Editors: Gunning, Peter (Ed.)

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About this book

A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

About the authors

PETER GUNNING, PhD, is Head of the Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, at the University of New South Wales located in Sydney, Australia. The primary focus of his research is the regulation of cell and tissue architecture and its modification in cancer. He is a member of numerous professional organisations and has served on the Boards of the NSW Cancer Council and Bio-Link Partners and as Chairman of the NSW Cancer Council and NSW Cancer Institute Research Committees. Peter received his academic degrees from Monash University, Melbourne, Australia.

Table of contents (22 chapters)

  • Introduction and Historical Perspective

    Gunning, Peter

    Pages 1-5

  • Structure and Evolution of Tropomyosin Genes

    Vrhovski, Bernadette (et al.)

    Pages 6-26

  • Tropomyosin Exons as Models for Alternative Splicing

    Gooding, Clare (et al.)

    Pages 27-42

  • Tropomyosin Gene Expression in Vivo and in Vitro

    Schevzov, Galina (et al.)

    Pages 43-59

  • Tropomyosin: Function Follows Structure

    Hitchcock-DeGregori, Sarah E.

    Pages 60-72

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-0-387-85766-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-387-85765-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
  • ISBN 978-1-4419-2760-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tropomyosin
Editors
  • Peter Gunning
Series Title
Advances in Experimental Medicine and Biology
Series Volume
644
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-85766-4
DOI
10.1007/978-0-387-85766-4
Hardcover ISBN
978-0-387-85765-7
Softcover ISBN
978-1-4419-2760-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIX, 304
Number of Illustrations and Tables
80 b/w illustrations, 8 illustrations in colour
Topics