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Regulatory T Cells and Clinical Application

Editors: Jiang, Shuiping (Ed.)

  • Covers one of the hottest topics in immunology today
  • Compiles recent developments in T cell immunobiology and clinical applications
  • Will have broad appeal to both researchers and clinicians
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eBook $189.00
price for USA (gross)
  • ISBN 978-0-387-77909-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-0-387-77908-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA
  • ISBN 978-1-4419-2670-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

A major process of rediscovery has taken place in the field of Cellular Immunology over the past 12 years—subsets of T lymphocytes exist that are specifically dedicated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses.

It was only after Prof. Sakaguchi identified the CD25 antigen in 1995 as a marker for a major population of T cells that had suppressor functions both in vitro and in vivo that the resurgence in the regulatory T cell area could begin.

The regulatory T cells field has grown dramatically over the past decade. It is now impossible to read a journal that does not contain numerous papers whose titles deal with regulatory T cells. More importantly, it is also difficult to submit a new research grant proposal in any area of immunologic research that does not include a section on analysis on the contribution of regulatory T cells to the subject matter under study.

Regulatory T cells can be best thought of today as "teenagers" ready to take on all the challenges of complex immune responses. In ten years, the field will certainly be more mature, and manipulation of regulatory T cell function by cellular biotherapy, antibodies and small molecules will be routine function of the clinical immunologist.

- From Preface by Prof. Ethan Shevach, National Institute of Health, USA

It has been for long debated whether suppressor/regulatory T cells did actually even exist. Today, this question is no longer accurate and the subject of regulatory T cells is the object of a constantly growing interest in immunologists and clinicians. There is no doubt that the history of Tregs will make a new big leap ahead.

- From Chapter One by Prof. Shimon Sakaguchi, Kyoto University, Japan

Table of contents (30 chapters)

  • γδ T Cells in Immunoregulation

    Tang, Long (et al.)

    Pages 1-6

  • Regulatory T Cells and the Control of Auto-Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Cells

    Miyara, Makoto (et al.)

    Pages 3-16

  • FoxP3 and Regulatory T Cells

    Kretschmer, Karsten (et al.)

    Pages 17-28

  • Thymic and Peripheral Generation of CD4 + Foxp3 + Regulatory T Cells

    Romagnoli, Paola (et al.)

    Pages 29-55

  • The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4 + CD25 + Foxp3 + Regulatory T Cells

    Bayer, Allison L. (et al.)

    Pages 57-76

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-0-387-77909-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA
  • ISBN 978-0-387-77908-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA
  • ISBN 978-1-4419-2670-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Regulatory T Cells and Clinical Application
Editors
  • Shuiping Jiang
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-77909-6
DOI
10.1007/978-0-387-77909-6
Hardcover ISBN
978-0-387-77908-9
Softcover ISBN
978-1-4419-2670-8
Edition Number
1
Number of Pages
XVIII, 590
Number of Illustrations and Tables
39 b/w illustrations, 32 illustrations in colour
Topics