Biotechnology: Pharmaceutical Aspects

Advances in Bioactivation Research

Editors: Elfarra, Adnan (Ed.)

  • Provides researchers with recent information on bioactivation reactions of drugs and toxicants

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About this book

I have always been interested in chemistry and biology. My undergraduate, graduate, and postdoctoral trainings in pharmacy, medicinal chemistry and pharmacology, respectively, have strengthened this interest and led me to realize that significant advances in medicine have frequently been realized because of research at the chem- try–biology interface. I am hoping that this comprehensive volume on recent advances in bioactivation research will stimulate pharmacologists, medicinal chemists, phar- ceutical scientists, and graduate students in these fields and related areas to consider and use bioactivation research when they explore and chart new frontiers in drug design and drug development and when they consider ways to reduce the side effects of existing drugs by making prodrugs. As for the toxicologists and environmental health scientists, I hope this volume will help them generate the knowledge needed to understand better mechanisms of toxicity to improve human risk assessments and intervention methods after occupational or environmental exposure to various hazardous chemicals. Adnan A. Elfarra, Ph. D. vii Part I General Concepts and Basic Mechanisms 1 Metabolic Concerns in Drug Design Jeffrey P. Jones Department of Chemistry, Washington State University, Pullman, WA 99164, USA e-mail: jpj@wsu. edu Keywords: Cytochrome P450 Aldehyde Oxidase Drug–Drug Interactions Mechanism-based Virtual Screening ADMET Regioselectivity 1. 1. Introduction Due to recent technological innovations, such as genomics, combinatorial chemistry, and high-throughput screening, the identification of disease targets and of compounds that are active against these targets (‘‘leads’’) can now be carried out efficiently.

About the authors

Dr. Elfarra received his B.S. degree in Pharmacy at Cairo University, Cairo, Egypt, in 1975 and his Ph.D. degree in Medicinal Chemistry at the University of Minnesota, Minneapolis, MN, in 1983. In 1985, Dr. Elfarra joined Shell Development Company in Houston, Texas as an associate research toxicologist after he completed his postdoctoral training in Pharmacology at the University of Rochester in Rochester, NY. Dr. Elfarra joined the University of Wisconsin-Madison as assistant professor in 1986. He was promoted to associate and full professor in 1992 and 1996, respectively. He served as the chair of the campus Biosafety Committee and has trained a large number of undergraduate students, graduate students, and postdoctoral students in his laboratory. He is the current director of the institutional training grant from NIEHS. Dr. Elfarra has served on the executive committee for the Division of Toxicology of the American Society for Pharmacology and Experimental Therapeutics, and has organized and participated in many national and international symposia focused on topics related to his research. He has served as consultant for many organizations, such as NIH, the National Research Council Board on Environmental Studies and Toxicology, the Health Effects Institute, Health Canada, and the International Agency for Research on Cancer.

Table of contents (17 chapters)

  • CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury

    Cederbaum, Arthur I.

    Pages 1-36

  • Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates

    Lin (et al.)

    Pages 1-34

  • Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes

    Murphy, Sharon E. (et al.)

    Pages 1-29

  • Hepatic Bioactivation and Drug-Induced Liver Injury

    Kemper, Raymond A. (et al.)

    Pages 1-33

  • One- and Two-Electron-Mediated Reduction of Quinones: Enzymology and Toxicological Implications

    Siegel, David (et al.)

    Pages 1-29

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-0-387-77300-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
  • ISBN 978-0-387-77299-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Bioactivation Research
Editors
  • Adnan Elfarra
Series Title
Biotechnology: Pharmaceutical Aspects
Series Volume
IX
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-77300-1
DOI
10.1007/978-0-387-77300-1
Hardcover ISBN
978-0-387-77299-8
Edition Number
1
Number of Pages
VII, 503
Topics