Medical Intelligence Unit

Immunosenescence

Editors: Pawelec, Graham (Ed.)

  • Addresses the mechanisms responsible for immune ageing in humans
  • Considers what might be accomplished to redress the erosion of immune competence with age
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eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-76842-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-76840-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-2639-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Human immunosenescence contributes to morbidity and mortality in later life. The age-associated increasing incidence of cancer and cardiovascular disease plateaus at around 80 years of age in industrialised countries, but death due to infectious disease continues to increase up to 100 years of age and beyond. Understanding the reasons for age-associated alterations to protective immunity in the elderly would facilitate the development of interventions to reconstitute appropriate immune function, increase responsiveness to vaccination and extend healthspan. The majority of the papers collected in this volume therefore address not only the mechanisms responsible for immune ageing in humans but consider what might be accomplished to redress the erosion of immune competence with age.

Reviews

From the reviews:

“The book covers the basic biology of cell-mediated immunity decline, the consequences of the declined immune system, and interventional therapeutic approaches aiming to correct or reverse the aged immune system. … The book ends with insightful review on therapeutic strategies aiming to correct or reverse immunosenescence. Overall, the book is very well written and should be recommended reading for cell biologists, immunologists, and physician scientists interested in the current scope of understanding immunosenscence and opportunities to explore therapeutic strategies for its correction.” (Yang Zhou, Clinical Infectious Diseases, December, 2012)


Table of contents (15 chapters)

  • Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study

    Wikby, Anders (et al.)

    Pages 1-14

  • Scoring of Immunological Vigor: Trial Assessment of Immunological Status as a Whole for Elderly People and Cancer Patients

    Hirokawa, Katsuiku (et al.)

    Pages 15-23

  • Remodelling of the CD8 T-Cell Compartment in the Elderly: Expression of NK Associated Receptors on T-Cells Is Associated with the Expansion of the Effector Memory Subset

    Gayoso, Inmaculada (et al.)

    Pages 24-33

  • Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infection

    Fauce, Steven R. (et al.)

    Pages 34-43

  • A Matter of Life and Death of T-Lymphocytes in Immunosenescence

    Gupta, Sudhir

    Pages 44-56

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-76842-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-76840-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-2639-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunosenescence
Editors
  • Graham Pawelec
Series Title
Medical Intelligence Unit
Copyright
2007
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-76842-7
DOI
10.1007/978-0-387-76842-7
Hardcover ISBN
978-0-387-76840-3
Softcover ISBN
978-1-4419-2639-5
Edition Number
1
Number of Pages
XVIII, 194
Number of Illustrations and Tables
41 b/w illustrations, 5 illustrations in colour
Topics