Biotechnology: Pharmaceutical Aspects

Immunogenicity of Biopharmaceuticals

Editors: Weert, Marco, Møller, Eva Horn (Eds.)

  • First book to address the potential of an immune response to the biopharmaceutical product

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-75841-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-75840-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-2608-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho’s blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies.

This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

Table of contents (13 chapters)

  • Immune Reactions Towards Biopharmaceuticals – a General, Mechanistic Overview

    Foged, Camilla (et al.)

    Pages 1-25

  • Clinical Aspects of Immunogenicity to Biopharmaceuticals

    Malucchi, Simona (et al.)

    Pages 27-56

  • Assessment of Unwanted Immunogenicity

    Wadhwa, Meenu (et al.)

    Pages 57-73

  • Models for Prediction of Immunogenicity

    Roggen, Erwin L.

    Pages 75-95

  • Immunogenicity of Biopharmaceuticals: Causes, Methods to Reduce Immunogenicity, and Biosimilars

    Weert, Marco van de (et al.)

    Pages 97-111

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-75841-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-75840-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-2608-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunogenicity of Biopharmaceuticals
Editors
  • Marco Weert
  • Eva Horn Møller
Series Title
Biotechnology: Pharmaceutical Aspects
Series Volume
VIII
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-75841-1
DOI
10.1007/978-0-387-75841-1
Hardcover ISBN
978-0-387-75840-4
Softcover ISBN
978-1-4419-2608-1
Edition Number
1
Number of Pages
XII, 266
Topics