Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

Editors: Vinks, Alexander, Derendorf, Hartmut, Mouton, Johan (Eds.)

  • The first book to deal with the theoretical aspects and with the clinical applications of pharmacokinetic and pharmacodynamic modeling in antimicrobial drug therapy
  • Discusses numerous topics including basic pharmacodynamic theory, pharmacokinetic complexities, and the use of in vitro and animal PK/PD models
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eBook $159.00
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  • ISBN 978-0-387-75613-4
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Hardcover $209.00
price for USA
  • ISBN 978-0-387-75612-7
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  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
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  • ISBN 978-1-4939-5081-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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About this book

Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development.

The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Reviews

From the reviews:

“The book’s first half can function as an advanced textbook and support learning these concepts and principles. The level and presentation are appropriate for learners who already have a reasonable grasp of general pharmacokinetics and pharmacodynamics, such as advanced graduate students, medical students, or pharmacy students. … The second half applies these principles to an in-depth analysis of pharmacokinetics/pharmacodynamics for classes of antimicrobial drugs. This treatment can enhance the understanding and the application of these concepts for even experienced practitioners.” (Gregory Reed, Doody’s Book Reviews, June, 2014)

Table of contents (17 chapters)

  • Introduction to Pharmacodynamics

    Craig, William A.

    Pages 3-22

  • In Vitro and Animal PK/PD Models

    Craig, William A.

    Pages 23-44

  • Setting Clinical MIC Breakpoints from a PK/PD Point of View: It Is the Dose That Matters

    Mouton, Johan W.

    Pages 45-61

  • Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling

    Wu, Benjamin (et al.)

    Pages 63-79

  • Pharmacodynamic In Vitro Models to Determine the Effect of Antibiotics

    Michael, Julia (et al.)

    Pages 81-112

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-0-387-75613-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-0-387-75612-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4939-5081-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
Editors
  • Alexander Vinks
  • Hartmut Derendorf
  • Johan Mouton
Copyright
2014
Publisher
Springer-Verlag New York
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-0-387-75613-4
DOI
10.1007/978-0-387-75613-4
Hardcover ISBN
978-0-387-75612-7
Softcover ISBN
978-1-4939-5081-2
Edition Number
1
Number of Pages
IX, 466
Number of Illustrations and Tables
98 b/w illustrations, 12 illustrations in colour
Topics