Biotechnology: Pharmaceutical Aspects

Drug Absorption Studies

In Situ, In Vitro and In Silico Models

Editors: Ehrhardt, Carsten, Kim, Kwang-Jin (Eds.)

  • Comprehensively summarizes the different approaches to assess drug absorption from in vitro models
  • Provides readers with a review of the current state-of-the-art in pharmaceutical cell biology
  • Provides readers with helpful protocols for many applications that can be directly used at the laboratory bench
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eBook $299.00
price for USA (gross)
  • ISBN 978-0-387-74901-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $379.00
price for USA
  • ISBN 978-0-387-74900-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening.

Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is  available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.

Table of contents (28 chapters)

  • Models for Skin Absorption and Skin Toxicity Testing

    Schaefer, Ulrich F. (et al.)

    Pages 3-33

  • Models of the Small Intestine

    Griffin, Brendan (et al.)

    Pages 34-76

  • Drug Absorption from the Colon In Situ

    Yuasa, Hiroaki

    Pages 77-88

  • In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa

    Nicolazzo, Joseph A. (et al.)

    Pages 89-111

  • In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies

    Agu, Remigius U. (et al.)

    Pages 112-134

Buy this book

eBook $299.00
price for USA (gross)
  • ISBN 978-0-387-74901-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $379.00
price for USA
  • ISBN 978-0-387-74900-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Drug Absorption Studies
Book Subtitle
In Situ, In Vitro and In Silico Models
Editors
  • Carsten Ehrhardt
  • Kwang-Jin Kim
Series Title
Biotechnology: Pharmaceutical Aspects
Series Volume
VII
Copyright
2008
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-74901-3
DOI
10.1007/978-0-387-74901-3
Hardcover ISBN
978-0-387-74900-6
Edition Number
1
Number of Pages
XXII, 696
Topics