Biotechnology: Pharmaceutical Aspects

Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

Editors: Augustijns, Patrick, Brewster, Marcus (Eds.)

  • Practical handbook as well as a reference allowing readers to make effective decisions concerning the use of solvents and solvent systems
  • Written by recognized experts from a number of fields
  • Includes useful decision trees, together with the scientific underpinning for their application, as well as trends in the use of solvent systems and a balance of current views
  • Useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations
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Buy this book

eBook $229.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-0-387-69154-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-0-387-69149-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-2402-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.

Table of contents (14 chapters)

  • Principles of Solubility

    GONG, YUCHUAN (et al.)

    Pages 1-27

  • Ionic Equilibria and the pH Dependence of Solubility

    BRITTAIN, HARRY G.

    Pages 29-51

  • Solvent Systems for Crystallization and Polymorph Selection

    MILLER, JONATHAN M. (et al.)

    Pages 53-109

  • Solubility Issues in Early Discovery and HTS

    DI, LI (et al.)

    Pages 111-136

  • Practical Aspects of Solubility Determination in Pharmaceutical Preformulation

    (TONY)TONG, WEI-QIN

    Pages 137-149

Buy this book

eBook $229.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-0-387-69154-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-0-387-69149-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-1-4419-2402-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics
Editors
  • Patrick Augustijns
  • Marcus Brewster
Series Title
Biotechnology: Pharmaceutical Aspects
Series Volume
VI
Copyright
2007
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-69154-1
DOI
10.1007/978-0-387-69154-1
Hardcover ISBN
978-0-387-69149-7
Softcover ISBN
978-1-4419-2402-5
Edition Number
1
Number of Pages
X, 462
Number of Illustrations and Tables
110 b/w illustrations, 9 illustrations in colour
Topics