The Kinetochore:

From Molecular Discoveries to Cancer Therapy

Editors: De Wulf, Peter, Earnshaw, William (Eds.)

  • Ties together the latest research into the workings of the kinetochore/centromere complex and neocentromeres; including what is known about their structure, how they function, how they are regulated, their involvement in the etiology of cancer, and how these structures might be targeted in cancer therapeutics

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eBook $139.00
price for USA (gross)
  • ISBN 978-0-387-69076-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-0-387-69073-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-4419-2398-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Table of contents (15 chapters)

  • Human Artificial Centromeres: De novo Assembly of Functional Centromeres on Human Artificial Chromosomes

    Masumoto, Hiroshi (et al.)

    Pages 1-26

  • Kinetochore-Microtubule Interactions

    Clayton, Lesley (et al.)

    Pages 1-24

  • The Kinetochore-Cancer Connection

    Tomonaga, Takeshi

    Pages 1-22

  • The Role of the Kinetochore in Spindle Checkpoint Signaling

    Stukenberg, P. Todd (et al.)

    Pages 1-26

  • The Basics of Chromosome Segregation

    Yanagida, Mitsuhiro

    Pages 1-24

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-0-387-69076-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.00
price for USA
  • ISBN 978-0-387-69073-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-4419-2398-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Kinetochore:
Book Subtitle
From Molecular Discoveries to Cancer Therapy
Editors
  • Peter De Wulf
  • William Earnshaw
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-69076-6
DOI
10.1007/978-0-387-69076-6
Hardcover ISBN
978-0-387-69073-5
Softcover ISBN
978-1-4419-2398-1
Edition Number
1
Number of Pages
XIII, 516
Topics