The Cancer Degradome

Proteases and Cancer Biology

Editors: Edwards, D., Hoyer-Hansen, G., Blasi, F., Sloane, B.F. (Eds.)

  • In the context of the battle against cancer, the Degradome is important in three principal areas:
  • Cellular proteases and their inhibitors are components of the molecular machinery of malignancy, and thus are attractive as therapeutic targets. Importantly, we now appreciate that some proteases perform functions that antagonize tumour growth, and these are then anti-targets that must be avoided
  • Degradome genes are valuable as prognostic and diagnostic markers of disease that can improve the accuracy of conventional clinical and histopathological assessment
  • Cellular proteases are target molecules for improving tumour detection and imaging
see more benefits

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-69057-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-69056-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.

Table of contents (41 chapters)

  • Protease Genomics and the Cancer Degradome

    Puente, Xose S. (et al.)

    Pages 3-15

  • The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes

    Kappelhoff, Reinhild (et al.)

    Pages 17-35

  • The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment

    Schwartz, Donald R. (et al.)

    Pages 37-47

  • Quantitative Real-Time PCR Analysis of Degradome Gene Expression

    Pennington, Caroline J. (et al.)

    Pages 49-65

  • Identification of Protease Substrates by Mass Spectrometry Approaches-1

    Enoksson, Mari (et al.)

    Pages 67-82

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-69057-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-69056-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Cancer Degradome
Book Subtitle
Proteases and Cancer Biology
Editors
  • Dylan Edwards
  • Gunilla Hoyer-Hansen
  • Francesco Blasi
  • B.F. Sloane
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-69057-5
DOI
10.1007/978-0-387-69057-5
Hardcover ISBN
978-0-387-69056-8
Edition Number
1
Number of Pages
XXIII, 926
Topics