Biotechnology: Pharmaceutical Aspects

Prodrugs

Challenges and Rewards

Editors: Stella, V., Borchardt, R., Hageman, M., Oliyai, R., Maag, H., Tilley, J. (Eds.)

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eBook $679.00
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  • ISBN 978-0-387-49785-3
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover $859.00
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  • ISBN 978-0-387-49782-2
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Softcover $859.00
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  • ISBN 978-1-4939-5050-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.

Reviews

From the reviews:

"The editors provide a comprehensive overview on early and current prodrug strategies. … medicinal chemists will highly appreciate this book. … the book should be available in the libraries of every pharmaceutical and small-molecule biotech company." (Hugo Kubinyi, ChemMedChem, Issue 3, 2008)


Table of contents (51 chapters)

  • A Case for Prodrugs

    Stella, Valentino J.

    Pages 3-33

  • Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs

    Valentino J. Stella

    Pages 37-82

  • Topical Delivery Using Prodrugs

    Kenneth B. Sloan, Scott C. Wasdo

    Pages 83-123

  • Prodrug approaches to ophthalmic drug delivery

    Tomi Järvinen, Riku Niemi

    Pages 125-155

  • Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery

    Tycho Heimbach, David Fleisher, Amal Kaddoumi

    Pages 157-215

Buy this book

eBook $679.00
price for USA (gross)
  • ISBN 978-0-387-49785-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $859.00
price for USA
  • ISBN 978-0-387-49782-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $859.00
price for USA
  • ISBN 978-1-4939-5050-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Prodrugs
Book Subtitle
Challenges and Rewards
Editors
  • Valentino Stella
  • Ronald Borchardt
  • Michael Hageman
  • Reza Oliyai
  • Hans Maag
  • Jefferson Tilley
Series Title
Biotechnology: Pharmaceutical Aspects
Series Volume
V
Copyright
2007
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-49785-3
DOI
10.1007/978-0-387-49785-3
Hardcover ISBN
978-0-387-49782-2
Softcover ISBN
978-1-4939-5050-8
Edition Number
1
Number of Pages
XVIII, 1464
Topics