Advances in Experimental Medicine and Biology

Mechanisms of Lymphocyte Activation and Immune Regulation XI

B Cell Biology

Editors: Gupta, S., Alt, F.W., Cooper, M.D., Melchers, F., Rajewsky, K. (Eds.)

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-46530-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-46527-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-4283-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Table of contents (1 chapters)

  • Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors

    Harinder Singh, Jagan M. R. Pongubala, Kay L. Medina

    Pages

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-46530-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-46527-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-4283-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Lymphocyte Activation and Immune Regulation XI
Book Subtitle
B Cell Biology
Editors
  • Sudhir Gupta
  • Frederick W. Alt
  • Max D. Cooper
  • Fritz Melchers
  • Klaus Rajewsky
Series Title
Advances in Experimental Medicine and Biology
Series Volume
596
Copyright
2007
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-46530-2
DOI
10.1007/0-387-46530-8
Hardcover ISBN
978-0-387-46527-2
Softcover ISBN
978-1-4419-4283-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 198
Number of Illustrations and Tables
44 b/w illustrations
Topics