Medical Intelligence Unit

Immunogenetics of Autoimmune Disease

Editors: Oksenberg, Jorge R., Brassat, David (Eds.)

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About this book

utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol­ ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent­ ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage­ ment approaches.

Table of contents (10 chapters)

  • HLA and Autoimmunity

    Wucherpfennig, Kai W.

    Pages 1-12

  • Genomic Variation and Autoimmune Disease

    Schmidt, Silke (et al.)

    Pages 13-27

  • Endocrine Diseases

    Bergholdt, Regine (et al.)

    Pages 28-40

  • Endocrine Diseases

    Ban, Yoshiyuki (et al.)

    Pages 41-58

  • Central and Peripheral Nervous System Diseases

    Chabas, Dorothée (et al.)

    Pages 59-74

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-39926-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-36004-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-9748-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunogenetics of Autoimmune Disease
Editors
  • Jorge R. Oksenberg
  • David Brassat
Series Title
Medical Intelligence Unit
Copyright
2006
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-39926-3
DOI
10.1007/978-0-387-39926-3
Hardcover ISBN
978-0-387-36004-1
Softcover ISBN
978-1-4899-9748-7
Edition Number
1
Number of Pages
XI, 158
Topics