Alzheimer's Disease

Advances in Genetics, Molecular and Cellular Biology

Editors: Sisodia, Sangram S., Tanzi, Rudolph E. (Eds.)

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-0-387-35135-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-0-387-35134-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4419-4195-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.

In 1906, Dr. Alois Alzheimer presented the case of his patient, Auguste D., a 51 year-old female admitted to the local asylum who presented with early memory impairments, psychoses, hallucinations and morbid jealousy. Dr. Alzheimer would argue that specific lesions that were present in and around neurons were responsible for dementia. In the ensuing decades, studies of the disorder that affected Auguste D., which would be named Alzheimer’s disease (AD), were largely limited to descriptive neuropathological and psychological assessments of this disease, but with little understanding of the molecular and cellular mechanisms underlying neurodegeneration and dementia.

This would change in the 1980s when the protein components of the major neuropathological hallmarks of the disease, senile plaques (and cerebral blood vessel amyloid) and neurofibrillary tangles were first determined. The identification of the ß-amyloid protein (Aß) and the microtubule-associated tau protein as the main components of plaques and tangles, respectively, would pave the way for the molecular genetic era of AD research. By the late-1980s, the genes encoding the ß-amyloid precursor protein (APP) and tau (MAPT) were identified and would subsequently be shown to harbor autosomal dominant mutations causing early-onset familial AD and frontal temporal dementia (FTD), respectively. In the early 1990s, the e4 variant of the apoliprotein E gene (APOE) would be found to be associated with increased risk for late-onset AD. APP mutations increased the generation and subsequent deposition of the neurotoxic peptide, Aß42, in brain while APOE-e4 affected aggregation of Aß into fibrils and its clearance from brain. In 1995, genes encoding presenilin 1 and 2 (PSEN1, PSEN2) were identified, and mutations in MAPT were linked to frontal temporal dementia. Thus, by 1995, the stage was set for molecular studies of age-related dementias with APP, presenilin 1 and 2, APOE, and tau playing the major roles.

The vast majority of studies addressing the molecular mechanisms underlying dementia would continue to focus on characterizing the five genes already firmly implicated in the etiology and pathogenesis of these dementing disorders, and these efforts have provided a firm foundation for translational studies that will hopefully serve to take these findings from the bench top to the bedside designing and developing novel ways to diagnose, treat, and prevent these diseases.

Table of contents (5 chapters)

  • The Genetics of Alzheimer’s Disease

    Lars Bertram MD

    Pages 1-16

  • Cognitive Impairment in Transgenic Aβ and Tau Models of Alzheimer’s Disease

    Karen H. Ashe

    Pages 77-91

  • Cholesterol and β-Amyloid

    Henri J. Huttunen, Dora M. Kovacs

    Pages 93-111

  • Tau Gene Mutations in FTDP-17 Syndromes

    Matthew J. Winton, John Q. Trojanowski, Virginia M -Y. Lee

    Pages 199-213

  • Tau and Axonal Transport

    Dr. Eva-Maria Mandelkow, E. Thies, E. Mandelkow

    Pages 237-256

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-0-387-35135-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-0-387-35134-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-1-4419-4195-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Alzheimer's Disease
Book Subtitle
Advances in Genetics, Molecular and Cellular Biology
Editors
  • Sangram S. Sisodia
  • Rudolph E. Tanzi
Copyright
2007
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-35135-3
DOI
10.1007/978-0-387-35135-3
Hardcover ISBN
978-0-387-35134-6
Softcover ISBN
978-1-4419-4195-4
Edition Number
1
Number of Pages
X, 286
Number of Illustrations and Tables
19 b/w illustrations, 5 illustrations in colour
Topics