Overview
- Authors:
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Christine Chaponnier
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Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
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Alexis Desmoulière
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Inserm E362, University of Bordeaux 2, Bordeaux, France
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Giulio Gabbiani
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Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
- Presents the most complete review to-date of the cell biology and pathology features of the myofibroblast as well as the mechanisms of fibrosis evolution in many organs and tissues
- Discusses the emerging concept of epithelial-mesenchimal cooperation in the processes of cancer invasion and metastasis formation
- Includes supplementary material: sn.pub/extras
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Table of contents (13 chapters)
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- Alexis Desmoulière, Christine Chaponnier, Giulio Gabbiani
Pages 1-6
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- Galina S. Bogatkevich, Anna Ludwicka-Bradley, Paul J. Nietert, Richard M. Silver
Pages 25-31
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- Carolyn J. Baglole, Terry J. Smith, David Foster, Patricia J. Sime, Steve Feldon, Richard P. Phipps
Pages 32-39
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- Michael Zeisberg, Mary A. Soubasakos, Raghu Kalluri
Pages 47-52
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- Abelardo Aguilera, Luiz S. Aroeira, Marta RamÃrez-Huesca, José A. Jiménez-Heffernan, Rafael Selgas, Manuel López-Cabrera
Pages 53-67
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- Olivier De Wever, Marc Mareel
Pages 74-87
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- Elvira Olaso, Beatriz Arteta, Clarisa Salado, Eider Eguilegor, Natalia Gallot, Aritz Lopategi et al.
Pages 88-101
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- Aqeel M. Jamil, John P. Iredale
Pages 102-109
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- Dianhua Jiang, Jennifer Hodge, Jiurong Liang, Paul W. Noble
Pages 110-117
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Back Matter
Pages 139-141
About this book
hirty-four years after the first description of the myofibroblast, the number of publications concerning this cell is very impressive and Tcontinuously expanding, and the work on the myofibroblast involves many laboratories throughout the world. The myofibroblast has been implicated in developmental and physiological phenomena, as well as in a variety of pathological situations, going from wound healing and fibrotic changes to asthma and cancer invasion. Many aspects of myofibroblast biology have been clarified, such as the role of TGF-P and ED-A cellular fibronectin in its differentiation and the role of a-smooth muscle actin in tension production by this cell; however several important problems concerning myofibroblast origin, ftmction and participation in pathological processes remain to be solved. The purpose of this book, as well of the Meeting "Tissue Repair, Contraction and the Myofibroblast" that took place in Nyon, near Geneva, Switzerland on November 18-20, 2004, is to put together the most recent advances in the understanding of myofibroblast biology and to present the main directions of research taking place worldwide to explore new aspects of myofibroblast physiological and pathological activities, such as: mechanisms of force generation by the myofibroblast; myofibroblast origin and diversity; interaction of the myofibroblast with other cells, normal and malignant epithelial cells in particular; and participation of the myofibroblast in the development of fibrosis in various organs. If we consider the animated and constructive discussions that took place during the Nyon Meeting, we are sure that this book will inspire new research in these fields.
