Handbook of Neurochemistry and Molecular Neurobiology

Neuroimmunology

Editors: Editor-in-chief: Lajtha, Abel
Galoyan, Armen, Besedovsky, Hugo (Eds.)

  • Contains essential data on multiple immunomodulators
  • Third edition with fresh material and corrections
  • A key text in a rapidly advancing field
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About this Reference Work

This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.

Reviews

From the reviews of the third edition:

"A new edition of the Handbook of Neurochemistry and Molecular Neurobiology has now been issued in 25 volumes. It contains fundamental data on current molecular neurobiology, neuroimmunology, and neuropathology. This is the first time that the series contain Neuroimmunology, which summarizes achievements in neurochemistry, neuroendocrinology, neurophysiology, and the pathology of the nervous system. … This book presents research performed by scientists in various countries. … a handbook for scientists, students, and clinicians." (K. G. Gevorgyan, Neurochemical Journal, Vol. 3 (1), 2009)


Table of contents (21 chapters)

  • Brain Cytokines as Integrators of the Immune–Neuroendocrine Network

    Besedovsky, H. O. (et al.)

    Pages 3-17

  • Neuropeptides in the Immune System: Mediators of Stress and Inflammation

    Jessop, D. S.

    Pages 19-35

  • Effects of the Immune System on Brain Neurochemistry

    Dunn, A. J.

    Pages 37-59

  • Age-Related Alterations in Autonomic Nervous System Innervation of Lymphoid Tissue

    Bellinger, D. L. (et al.)

    Pages 61-81

  • Drugs that Target Sympathetic–Immune Pathways for Treatment of Autoimmune Diseases

    Lorton, D. (et al.)

    Pages 83-121

Buy this book

eReference $249.00
price for USA (gross)
  • ISBN 978-0-387-30398-7
  • Free shipping for individuals worldwide
Print $249.00
price for USA
  • ISBN 978-0-387-30358-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Handbook of Neurochemistry and Molecular Neurobiology
Book Subtitle
Neuroimmunology
Editors
  • Abel Lajtha
  • Armen Galoyan
  • Hugo Besedovsky
Copyright
2008
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eReference ISBN
978-0-387-30398-7
Print ISBN
978-0-387-30358-1
Edition Number
3
Number of Pages
XIII, 495
Topics