Emerging Infectious Diseases of the 21st Century

Malaria

Genetic and Evolutionary Aspects

Editors: Dronamraju, Krishna R., Arese, Paolo (Eds.)

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About this book

This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.

Reviews

From the reviews:

"Malaria focuses on genetic and evolutionary insights into a paradise blamed for the death of a child every 30 s worldwide. … Malaria: Genetic and Evolutionary Aspects will benefit a broad range of medical, scientific, and public health professionals. Besides strengthening our understanding of the evolutionary origins of malaria, the text opens new perspectives into infectious diseases." (Richard A. Stein, American Journal of Physical Anthropology, Vol. 133, 2007)


Table of contents (4 chapters)

  • Clinical, Epidemiological, and Genetic Investigations on Thalassemia and Malaria in Italy

    Stefano Canali, Gilberto Corbellini

    Pages 55-80

  • Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors

    Rajeev K. Mehlotra, Peter A. Zimmerman

    Pages 81-124

  • Evolutionary Origins of Human Malaria Parasites

    Stephen M. Rich, Francisco J. Ayala

    Pages 125-146

  • Disease and Evolution

    J. B. S. Haldane

    Pages 175-187

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-0-387-28295-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.00
price for USA
  • ISBN 978-0-387-28294-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.00
price for USA
  • ISBN 978-1-4419-2102-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Malaria
Book Subtitle
Genetic and Evolutionary Aspects
Editors
  • Krishna R. Dronamraju
  • Paolo Arese
Series Title
Emerging Infectious Diseases of the 21st Century
Copyright
2006
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-28295-4
DOI
10.1007/0-387-28295-5
Hardcover ISBN
978-0-387-28294-7
Softcover ISBN
978-1-4419-2102-4
Edition Number
1
Number of Pages
XI, 190
Number of Illustrations and Tables
26 b/w illustrations
Topics