Authors:
- Focuses on functional aspects of DNA structures (conformations), rather than structure and conformation themselves
- Description of human triplet-repeat diseases and mechanisms of mammalian sex determination
- The first book to compile the results of +studies that have been performed to date to solve the riddle ‘written’ in DNA conformation
- Covers almost all of the "famous" DNA structures (conformations) and focuses on their functions in transcription
Part of the book series: Molecular Biology Intelligence Unit (MBIU)
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Table of contents (14 chapters)
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Front Matter
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Multifarious DNA Structures Found In Genomes
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Front Matter
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Intrinsic DNA Curvature and Transcription
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Front Matter
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Implied Roles of Left-Handed Z-DNA, Triplex DNA, DNA Supercoiling, and Miscellaneous Alternative Conformations of DNA in Transcription
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Front Matter
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DNA-Bending Proteins: Architectural Regulation of Transcription
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Front Matter
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Chromatin Infrastructure in Transcription: Roles of DNA Conformation and Properties
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Front Matter
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About this book
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Authors and Affiliations
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Department of Biology Faculty of Science and Engineering, Konan University, Kobe, Japan
Takashi Ohyama
Bibliographic Information
Book Title: DNA Conformation and Transcription
Authors: Takashi Ohyama
Series Title: Molecular Biology Intelligence Unit
DOI: https://doi.org/10.1007/0-387-29148-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2005
Hardcover ISBN: 978-0-387-25579-8Published: 16 August 2005
Softcover ISBN: 978-1-4899-9507-0Published: 01 December 2014
eBook ISBN: 978-0-387-29148-2Published: 26 February 2007
Series ISSN: 1431-0414
Edition Number: 1
Number of Pages: XIV, 211
Topics: Anatomy, Biochemistry, general, Cell Biology, Human Genetics, Molecular Medicine