Overview
- The ADAM Family of Proteases will be a timely and useful source of information both for those immersed in the field and those just entering this exciting and rapidly expanding field of research. The individual chapters have been written by pioneers and experts in this area
- Provides an up-to-date presentation of the role of ADAM and ADAMTS proteases in biological processes
- Highlights the critical role played by these metalloproteases in various diseases
- Provides background information on the genetics, structure and function of each ADAM and ADAMTS protease
- Includes supplementary material: sn.pub/extras
Part of the book series: Proteases in Biology and Disease (PBAD, volume 4)
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Table of contents (15 chapters)
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Front Matter
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Back Matter
Keywords
About this book
The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
Editors and Affiliations
Bibliographic Information
Book Title: The ADAM Family of Proteases
Editors: Nigel M. Hooper, Uwe Lendeckel
Series Title: Proteases in Biology and Disease
DOI: https://doi.org/10.1007/b106833
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2005
Hardcover ISBN: 978-0-387-25149-3Published: 23 June 2005
Softcover ISBN: 978-1-4419-3775-9Published: 05 January 2011
eBook ISBN: 978-0-387-25151-6Published: 02 July 2006
Edition Number: 1
Number of Pages: XIV, 344
Topics: Biochemistry, general