Proteases in Biology and Disease

The ADAM Family of Proteases

Editors: Hooper, Nigel M, Lendeckel, Uwe (Eds.)

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About this book

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

Table of contents (5 chapters)

  • Introduction to the ADAM Family

    Judith White, Lance Bridges, Douglas DeSimone, et al.

    Pages 1-28

  • ADAM12

    Ulla M. Wewer, Reidar Albrechtsen, Eva Engvall

    Pages 123-146

  • Mammalian ADAMs with Testis-Specific or -Predominant Expression

    Chunghee Cho

    Pages 239-259

  • ADAMTS3 and ADAMTS14

    Carine Le Goff, Suneel S. Apte

    Pages 283-298

  • ADAMTS-4 and ADAMTS-5

    Anne-Marie Malfait, Micky Tortorella, Elizabeth Arner

    Pages 299-322

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-25151-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-387-25149-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-3775-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The ADAM Family of Proteases
Editors
  • Nigel M Hooper
  • Uwe Lendeckel
Series Title
Proteases in Biology and Disease
Series Volume
4
Copyright
2005
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-25151-6
DOI
10.1007/b106833
Hardcover ISBN
978-0-387-25149-3
Softcover ISBN
978-1-4419-3775-9
Edition Number
1
Number of Pages
XIV, 344
Topics