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Statistics for Biology and Health

Bioinformatics and Computational Biology Solutions Using R and Bioconductor

Editors: Gentleman, R., Carey, V., Huber, W., Irizarry, R., Dudoit, S. (Eds.)

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  • ISBN 978-0-387-29362-2
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Hardcover $189.00
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About this book

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including

importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms

curation and delivery of biological metadata for use in statistical modeling and interpretation

statistical analysis of high-throughput data, including machine learning and visualization,

modeling and visualization of graphs and networks.

The developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies.

This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

Robert Gentleman is Head of the Program in Computational Biology at the Fred Hutchinson Cancer Research Center in Seattle. He is one of the two authors of the original R system and a leading member of the R core team. Vincent Carey is Associate Professor of Medicine (Biostatistics), Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School. Gentleman and Carey are co-founders of the Bioconductor project. Wolfgang Huber is Group Leader in the European Molecular Biology Laboratory at the European Bioinformatics Institute in Cambridge. He has made influential contributions to the error modeling of microarray data. Rafael Irizarry is Associate Professor of Biostatistics at the Johns Hopkins Bloomberg School of Public Health in Baltimore. He is co-developer of RMA and GCRMA, two of the most popular methodologies for preprocessing high-density oligonucleotide arrays. Sandrine Dudoit is Assistant Professor in the Department of Biostatistics at the University of California, Berkeley. She has made seminal discoveries in the fields of multiple testing and generalized cross-validation and spearheaded the deployment of these findings in applied genomic science.

Reviews

From the reviews:

"The book has several nice touches that readers will appreciate. First, the liberal use of color shows the full capabilities of Bioconductor pakages and brings the material to life. Second, color figures are dispersed throughout the text rather than being relegated to a central section of color plates. Third, the index indicates whether a term references a package, function or class. This book is an excellent resource... In summary, this book is a must have for any Bioconductor user." (J. Wade Davis, Journal of the American Statistical Association, Vol. 102, No. 477, 2007)

"This book is solid evidence of the influence that quantitative researchers can have on biological investigations. Organized into separate chapters of shared authorship, the book provides a valuable overview of the impact that the authors and their colleagues have had on the analysis of genomic data." (R.W. Doerge, Biostatistics, December 2006)

"This book provides an in-depth demonstration of the potential of the Bioconductor project, through a varied mixture of descriptions, figures and examples. … The book … is an exciting opportunity for researchers to learn directly from the software developers themselves. The range of material covered by the book is diverse and well structured. An abundance of fully worked case studies illustrate the methods in practice. … it should be a must for any researcher considering getting started with the software … ." (Rebecca Walls, Journal of Applied Statistics, Vol. 34 (3), 2007)

"The book provides an extensive overview over the most important tasks in analyzing genomic data with Bioconductor. … The book is well written and communicates hands-on experience of the developers of the respective Bioconductor packages themselves. … The book is targeted to a broad range of researchers interested in genomic data analysis, including biologists, bioinformaticians, and statisticians. … It is a very valuable resource for modern genomic data analysis. There is no comparable book on the market." (Jörg Rahnenführer, Statistical Papers, Vol. 50, 2009)


Table of contents (9 chapters)

  • Preprocessing Overview

    W. Huber, R. A. Irizarry, R. Gentleman

    Pages 3-12

  • Quality Assessment of Affymetrix GeneChip Data

    B. M. Bolstad, F. Collin, J. Brettschneider, et al.

    Pages 33-47

  • Preprocessing Two-Color Spotted Arrays

    Y. H. Yang, A. C. Paquet

    Pages 49-69

  • Interactive Outputs

    C. A. Smith, W. Huber, R. Gentleman

    Pages 147-160

  • Analysis of Differential Gene Expression Studies

    D. Scholtens, A. von Heydebreck

    Pages 229-248

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-0-387-29362-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-0-387-25146-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Bioinformatics and Computational Biology Solutions Using R and Bioconductor
Editors
  • Robert Gentleman
  • Vincent Carey
  • Wolfgang Huber
  • Rafael Irizarry
  • Sandrine Dudoit
Series Title
Statistics for Biology and Health
Copyright
2005
Publisher
Springer-Verlag New York
Copyright Holder
The Editor(s) (if applicable) and The Author(s) 2018
Distribution Rights
Distribution rights for India: Researchco Book Centre, New Delhi, India
eBook ISBN
978-0-387-29362-2
DOI
10.1007/0-387-29362-0
Hardcover ISBN
978-0-387-25146-2
Series ISSN
1431-8776
Edition Number
1
Number of Pages
XX, 474
Number of Illustrations and Tables
128 illustrations in colour
Topics