Advances in Experimental Medicine and Biology

Multichain Immune Recognition Receptor Signaling

From Spatiotemporal Organization to Human Disease

Editors: Sigalov, Alexander (Ed.)

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About the authors

ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity in the context of transmembrane signal transduction, the molecular mechanisms underlying immune receptor-mediated signaling and ways to control these processes and thus to modulate the immune response, as well as the development and applications of novel targets and strategies for innovative immune therapy. He discovered and investigated a very unusual and unique biophysical phenomenon, the homooligomerization of intrinsically disordered proteins, thus providing the first evidence for the existence of specific interactions between unfolded protein molecules. In the field of immunology, he unraveled a long-standing mystery of transmembrane signaling and immune cell activation triggered by multichain immune recognition receptors. Later, he developed a novel concept of platelet inhibition and invented a novel class of platelet inhibitors. In the field of immune therapy, he proposed new therapeutic strategies for a variety of malignancies and immune disorders, including immunodeficiencies, inflammatory and autoimmune diseases, allergy and HIV. He is a member of the American Association for the Advancement of Science and the Biophysical Society, USA. Alexander Sigalov received his academic degrees (MSc in Chemistry and a PhD in Organic Chemistry) from Moscow State University, Russia.

Table of contents (2 chapters)

  • Immune Receptor Signaling, Aging and Autoimmunity

    Anis Larbi, Tamas Fülöp, Graham Pawelec

    Pages

  • MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines

    Vasso Apostolopoulos, Eliada Lazoura, Minmin Yu

    Pages

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-0-387-09789-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-0-387-09788-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-1-4419-1887-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Multichain Immune Recognition Receptor Signaling
Book Subtitle
From Spatiotemporal Organization to Human Disease
Editors
  • Alexander Sigalov
Series Title
Advances in Experimental Medicine and Biology
Series Volume
640
Copyright
2008
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-09789-3
DOI
10.1007/978-0-387-09789-3
Hardcover ISBN
978-0-387-09788-6
Softcover ISBN
978-1-4419-1887-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXVII, 357
Number of Illustrations and Tables
67 b/w illustrations, 3 illustrations in colour
Topics