Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases

A New Perspective

Authors: Langham, Maurice E.

  • Offers decisive guidance on the practical aspects for early diagnosis and treatment of ocular and cerebral diseases for clinicians in ophthalmology, neurology, medicine, optometry and geriatrics
  • Brings together fifty years of research on the physiology of intraocular pressure and ocular blood flow and their relation to early diagnosis and therapy of vascular diseases of the eye and brain
  • Presents evidence that ischemia and loss of autoregulation of blood flow are associated with the onset of the major ocular and cerebral diseases including macular degeneration, diabetic retinopathy, low and normal tension open angle glaucoma, stroke and Alzheimer’s disease
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eBook $109.00
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  • ISBN 978-0-387-09716-9
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  • Immediate eBook download after purchase
Hardcover $139.00
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  • ISBN 978-0-387-09715-2
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About this book

Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases: A New Perspective presents evidence that ischemia and loss of autoregulation of blood flow are associated with the onset of the major ocular and cerebral diseases including macular degeneration, diabetic retinopathy, low and normal tension open angle glaucoma, stroke and Alzheimer’s disease. Recognition of these vascular changes underline the critical need for clinicians to monitor blood flow and autoregulation to improve early diagnosis and to optimize therapies of ocular and cerebral vascular diseases. The text brings to clinicians in Ophthalmology, Neurology, Medicine, Optometry and Geriatrics decisive guidance on the practical aspects for early diagnosis and treatment of ocular and cerebral diseases.

The author brings together in a concise form the progress made over the span of his career and provides new perspectives and understanding of the fluid circulations of the eye and the brain. In addition, he explains the new analytical technologies that made the new concepts possible. The physiological and functional importance of blood flow autoregulation in the eye and in the brain in minimizing the progression of pathology, including the ischemia resulting from stenosis of the internal carotid artery and stroke, are also presented .

ABOUT THE AUTHOR: Dr. Langham was born in London, England. In 1947, he joined the Ophthalmological Research Unit, newly formed by the Medical Research Council of the United Kingdom under the direction of Sir Stewart Duke-Elder. In 1956, the author enjoyed a research fellowship at Harvard University. After returning to England for a time, he accepted a position of Associate Professor of Ophthalmology and Director of Research at the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and Medical school in 1959. There he initiated a program in which all residents spent time engaged in research. This productive interaction between the disciplines led to many important clinical diagnostic and therapeutic advances.

Reviews

From the reviews:

"This monograph is primarily an extensive review of the literature on intraocular pressure and any other pressures having to do with the eye. … A major value of this monograph is the wealth of primary citations to literature that predates PubMed. … this monograph could have used some anatomical figures and diagrams in the beginning chapters to go along with the physiological descriptions because the monograph is very approachable to interested readers who may not be currently working in the eye." (Joseph C. LaManna, Journal of Alzheimer’s Disease, Vol. 18, 2009)

"Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases: A New Perspective summarizes a life’s work dedicated to understanding how a complex interaction of factors, such as intraocular pressures, ocular perfusion, and autoregulation affect ocular health. As such, this sole-authored text explores the … interests of most practicing ophthalmologists and neuroradiologists. … The illustrations, graphs, and line drawings have been carefully selected and help the author present a compelling story of the value of this approach to understanding the pathophysiology of ocular disease." (American Journal of Neuroradiology, September, 2009)


Table of contents (32 chapters)

  • Concepts and New Perspectives

    Langham, Maurice E.

    Pages 1-2

  • “In Vivo” Manometric Studies of the Steady State Intraocular Pressure and the Intraocular Pressure Pulse in Animals and Man

    Langham, Maurice E.

    Pages 1-9

  • The Rate of Formation of the Aqueous Humor

    Langham, Maurice E.

    Pages 11-14

  • The Steady State Intraocular Pressure/Flow Relations in Dead and Living Animal and Human Eyes

    Langham, Maurice E.

    Pages 15-18

  • Homeostasis, Autoregulation, and Relative Ischemia

    Langham, Maurice E.

    Pages 19-26

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-0-387-09716-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-0-387-09715-2
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
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Bibliographic Information

Bibliographic Information
Book Title
Ischemia and Loss of Vascular Autoregulation in Ocular and Cerebral Diseases
Book Subtitle
A New Perspective
Authors
Copyright
2009
Publisher
Springer-Verlag New York
Copyright Holder
Springer-Verlag New York
eBook ISBN
978-0-387-09716-9
DOI
10.1007/978-0-387-09716-9
Hardcover ISBN
978-0-387-09715-2
Edition Number
1
Number of Pages
XIX, 193
Topics