Immunobiology of Organ Transplantation

1. Front Matter

   Pages i-xxvii

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2. Introduction and Overview

   1. Introduction and Overview

      • Charles Orosz

      Pages 1-3

3. Overview of Immunity in Transplantation

   1. Front Matter

      Pages 5-5

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   2. Immunity of Allograft Rejection: An Overview

      • Worakij Chalermskulrat, Isabel R Neuringer, Robert M. Aris

      Pages 7-27

   3. MHC: Structure and Function

      • Sophie Candon, David H Margulies

      Pages 29-44

   4. HLA Immunogenetics and Transplantation

      • Frans H. J. Claas

      Pages 45-52

   5. Extracellular Processing of MHC Class I Antigens

      • Yuri Bushkin, Hidehiro Watanabe, Sandra Demaria

      Pages 53-65

   6. Genetics of CD1 Molecules

      • Randy R. Brutkiewicz

      Pages 67-69

   7. Minor Histocompatibility Antigens: Molecular Barriers for Successful Tissue Transplantation

      • Subramaniam Malarkannan, Laura.M Pooler

      Pages 71-105

   8. Mechanisms of Allorecognition

      • Gilles Benichou, Yoshinobu Akiyama, Jill Roughan, Yoshiko Iwamoto, Georges Tocco

      Pages 107-137

   9. Complement System in Allorecognition and Rejection of Organ Transplants

      • William M. Baldwin III, Hirofumi Ota, Barbara A. Wasowska, E. Rene Rodriguez

      Pages 139-158

   10. Xenotransplantation

       • Anita S. Chong, Ian A. Boussy, Guerard W. Byrne

       Pages 159-169

   11. Conceptual Models in Immunity/Tolerance: Application to Transplantation

       • Colin C. Anderson

       Pages 171-190

4. Antigen-Presenting Cells

   1. Front Matter

      Pages 191-191

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   2. Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance

      • Kena A. Swanson, David S. Wilkes

      Pages 193-222

   3. Monocytes and Macrophages in Transplantation

      • Laurent P. Nicod, S. Ferrari-Lacraz

      Pages 223-240

   4. Role of B Lymphocytes and Alloantibodies in Organ Transplantation

      • Barbara A. Wasowska, William M. Baldwin III

      Pages 241-264

5. T Cells, Natural Killer Cells, NK-T Cells

   1. Front Matter

      Pages 265-265

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   2. Overview of T-Cell Phenotype and Function

      • Peter S. Heeger

      Pages 267-290

   3. Costimulatory Molecules in T CeII Activation and Transplantation

      • Robert H. Arch, M. Jonathan Green

      Pages 291-312

Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels.
The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

• Antigen
• Chemokine
• atherosclerosis
• cell biology
• cytokine
• genetics
• histocompatibility
• immunobiology
• infection
• lymphocytes
• macrophages
• organ
• organ transplantation
• transplantation

• Microbiology and Immunobiology, Division of Pulmonary and Critical Care Medicine, Indiana University School of Medicine, Indianapolis

  David S. Wilkes

• Department of Surgery, Division of Transplantation, University of Wisconsin, Madison

  William J. Burlingham

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