Proteases in Biology and Disease

Proteases in Tissue Remodelling of Lung and Heart

Editors: Lendeckel, Uwe, Hooper, Nigel M. (Eds.)

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About this book

Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data.

Proteases in Tissue Remodelling of Lung and Heart:
*is devoted to proteases in lung and heart specifically and extensively,
*covers major diseases of the lung and heart,
*extensively introduces individual proteases (or families thereof),
*presents up-to-date patient-derived and experimental data,
*covers most aspects of protease function in disease.

About the authors

Uwe Lendeckel is a Reader at the Institute of Experimental Internal Medicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph.D in biochemistry in 1990 from the Ernst-Moritz-Arndt University of Greifswald. His thesis on the "expression of the pro-opiomelanocortin gene in rat Islets of Langerhans and other tissues" stimulated his interest in the neuro-immunological cross-talk and the regulatory roles of cell surface proteases therein. In 1989 he joined the ectopeptidase research group at the University of Magdeburg and since then continues to study regulation of expression and the function of T cell ectopeptidases in the normal and pathological immune response, with special focus on the membrane alanyl-aminopeptidase. He has published over 40 research papers. Nigel Hooper is Professor of Biochemistry in the School of Biochemistry and Molecular Biology at the University of Leeds, UK. He received his Ph.D in 1984 from the University of Leeds with a thesis on the "Metabolism of Neuropeptides by Cell-surface Peptidases" which stimulated his interest in proteases and paved the way for much of his subsequent research. He currently co-leads the Proteolysis Research Group at Leeds and among other topics, continues to study the structure and function of several cell-surface proteases, with a particular interest in their mode of attachment to the membrane. He has published over 90 research papers, edited 4 books and co-authored the widely acclaimed undergraduate textbook Instant Notes Biochemistry.

Table of contents (10 chapters)

  • Human leukocyte elastase and cystic fibrosis

    Cantin, André M. (et al.)

    Pages 1-33

  • Matrix Metalloproteinases in inflammation of the lung

    St-Pierre, Yves (et al.)

    Pages 35-56

  • Proteases in interstitial lung diseases

    Wille, Aline (et al.)

    Pages 57-73

  • Matrix Metalloproteinase Inhibitors in Cancer Therapy

    Purcell, W. Thomas (et al.)

    Pages 75-118

  • The Role of Proteases in the Pathogenesis of Lung Emphysema

    Golpon, Heiko (et al.)

    Pages 119-126

Buy this book

eBook $139.00
price for USA (gross)
  • ISBN 978-1-4419-9082-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-0-306-47910-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.00
price for USA
  • ISBN 978-1-4613-4786-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteases in Tissue Remodelling of Lung and Heart
Editors
  • Uwe Lendeckel
  • Nigel M. Hooper
Series Title
Proteases in Biology and Disease
Series Volume
1
Copyright
2003
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4419-9082-2
DOI
10.1007/978-1-4419-9082-2
Hardcover ISBN
978-0-306-47910-6
Softcover ISBN
978-1-4613-4786-6
Edition Number
1
Number of Pages
XVI, 237
Topics