Molecular Biology Intelligence Unit

Molecular Biology of the Parathyroid

Editors: Naveh-Many, Tally (Ed.)

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eBook $199.00
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  • ISBN 978-0-387-27530-7
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About this book

aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu­ M lar calcium levels, by acting on bone, kidney and intestine. The recent intro­ duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper­ plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres­ sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha­ nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para­ thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex­ pression to its intracellular processing and the sequences in the gene control­ ling its transcription as well as those regulating mRNA processing, stability and translation are described.

Table of contents (1 chapters)

  • Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism

    Trisha M. Shattuck, Sanjay M. Mallya, Andrew Arnold

    Pages 140-158

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-0-387-27530-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-306-47847-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4419-3415-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Biology of the Parathyroid
Editors
  • Tally Naveh-Many
Series Title
Molecular Biology Intelligence Unit
Copyright
2005
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-0-387-27530-7
DOI
10.1007/0-387-27530-4
Hardcover ISBN
978-0-306-47847-5
Softcover ISBN
978-1-4419-3415-4
Series ISSN
1431-0414
Edition Number
1
Number of Pages
XIV, 199
Number of Illustrations and Tables
66 b/w illustrations, 5 illustrations in colour
Additional Information
Jointly published with Landes Bioscience, Austin, TX, USA
Topics