The Filaria

1. Front Matter

   Pages i-viii

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2. Lymphatic Filarial Infections: An Introduction to the Filariae

   • J. W. Kazura

   Pages 1-8

3. Vector-Parasite Interactions in Mosquito-Borne Filariasis

   • L.C. Bartholomay, B.M. Christensen

   Pages 9-19

4. Evolutionary Relationships Among Filarial Nematodes

   • Odile Bain

   Pages 21-29

5. Filarial Genomics: Gene Discovery and Gene Expression

   • S.A. Williams, S.J. Laney

   Pages 31-42

6. The Epidemiology of Onchocerciasis and the Long Term Impact of Existing Control Strategies on this Infection

   • Peter Fischer, Dietrich W. Büttner

   Pages 43-57

7. The Epidemiology of Filariasis Control

   • Edwin Michael

   Pages 59-74

8. Host Factors, Parasite Factors, and External Factors Involved in the Pathogenesis of Filarial Infections

   • David O. Freedman

   Pages 75-86

9. Natural History of Human Filariasis — The Elusive Road

   • Balachandran Ravindran

   Pages 87-96

10. In Utero Exposure to Filarial Antigens and Its Influence on Infection Outcomes

    • Patrick J. Lammie

    Pages 97-107

11. Immune Effectors Important in Protective Resistance

    • Achim Hoerauf

    Pages 109-125

12. Immune Regulation and the Spectrum of Filarial Disease

    • Christopher L. King

    Pages 127-142

13. Wolbachia Bacterial Endosymbionts

    • Mark J. Taylor

    Pages 143-153

14. Approaches to the Control and Elimination of the Clinically Important Filarial Diseases

    • C. D. Mackenzie, M. Malecela, Mueller I., M.A. Homeida

    Pages 155-165

15. Vaccines for Filarial Infections

    • Paul B. Keiser, Thomas B. Nutman

    Pages 167-178

16. Back Matter

    Pages 179-181

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Filarial nematodes constitute and important group of human pathogens in tropical regions of the world. Diseases associated with these worms are generally separated into two categories: filariasis, caused by infections of lymphatic dwelling parasites and onchocerciasis, or river blindness, caused by infections of Onchocerca volvulus. Other filariae specifically infect humans and it is likely that zoonotic filarial infections may alter the outcome of infections with human parasites. The chapters in this book will cover concepts that, in most instances, overlap all of these parasites as well as focus on new and emerging ideas.
The Filaria, volume five of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

• antigen
• biology
• epidemiology
• evolution
• gene
• gene expression
• genomics
• infection
• morphology
• parasite
• parasites
• pathogenesis
• taxonomy
• vaccine

Thomas R. Klei is a Boyd Professor and Associate Dean for Research and Advanced Studies, School of Veterinary Medicine, Louisiana, Baton Rouge, LA. T.V. Rajan is a Professor at the School of Medicine, University of Connecticut Health Center, Farmington, USA

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