Infectious Agents and Pathogenesis

Human Retroviral Infections

Immunological and Therapeutic Control

Editors: Ugen, Kenneth E., Bendinelli, Mauro, Friedman, Herman (Eds.)

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Hardcover $319.00
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About this book

The discovery of the human T cell leukemia virus type I in the late 1970s heralded a new era in retrovirology. For the first time, it was demonstrated that a retrovirus could play a role in the development of a human disease, in this case adult T cell leukemia (ATL). Several years later, the acquired immunodeficiency syndrome (AIDS) epidemic began, and it was dem- strated that a retrovirus, originally designated the human T cell lymp- tropic virus type 3, was the causal agent of this syndrome. This virus, later named the human immunodeficiency virus type 1 (HIV-1), has since been extensively studied in terms of its pathogenesis as well as its ability to elicit immune responses. In that time, a tremendous amount of information has been obtained about the virus. Although recent drug regimens have been useful in significantly lowering viral loads and perhaps maintaining an asymptomatic state among individuals infected with HIV-1, an established “cure” for AIDS eludes us. In addition, the effective drug therapies are very expensive, and are not available to infected people in the third world, where greater than 90% of new infections occur. Furthermore, the development of viral resistance against the drug therapies is an additional concern. Despite extensive study, no effective vaccine has been developed. One of the problems in developing an effective vaccine against HIV-1 is the ability of the virus, particularly in the immunogenic envelop glycoprotein, to undergo amino acid hypervariability.

Table of contents (15 chapters)

  • The Two Principal Viremias of HIV

    Bristow, Cynthia L.

    Pages 1-16

  • Potential Role of Human T-cell Leukemia/Lymphoma Viruses (HTLV) in Diseases Other Than Acute T-cell Leukemia/Lymphoma (ATL)

    Gentile, Teresa C. (et al.)

    Pages 17-28

  • Viral-Related Proteins in Immune Dysfunction Associated with AIDS

    Cianciolo, George J.

    Pages 29-60

  • Carbohydrate Interactions and HIV-1

    Kieber-Emmons, Thomas

    Pages 61-85

  • HTLV-I and HTLV-II Infection

    Bennett, Mosi K. (et al.)

    Pages 87-107

Buy this book

eBook $249.00
price for USA (gross)
  • ISBN 978-0-306-46819-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $319.00
price for USA
  • ISBN 978-0-306-46222-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $319.00
price for USA
  • ISBN 978-1-4757-8168-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Human Retroviral Infections
Book Subtitle
Immunological and Therapeutic Control
Editors
  • Kenneth E. Ugen
  • Mauro Bendinelli
  • Herman Friedman
Series Title
Infectious Agents and Pathogenesis
Copyright
2002
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-0-306-46819-3
DOI
10.1007/b111099
Hardcover ISBN
978-0-306-46222-1
Softcover ISBN
978-1-4757-8168-7
Series ISSN
1075-1289
Edition Number
1
Number of Pages
XXII, 368
Topics