Pharmaceutical Biotechnology

Integration of Pharmaceutical Discovery and Development

Case Histories

Editors: Borchardt, R.T., Freidinger, R.M., Sawyer, T.K., Smith, P.L. (Eds.)

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About this book

In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

Table of contents (25 chapters)

  • Introduction

    Hirschmann, Ralph

    Pages 1-5

  • Renin Inhibitors

    Rosenberg, Saul H. (et al.)

    Pages 7-28

  • The Discovery and Development of Angiotensin II Antagonists

    Carini, David J. (et al.)

    Pages 29-56

  • Development of an Orally Active Tripeptide Arginal Thrombin Inhibitor

    Shuman, Robert T. (et al.)

    Pages 57-80

  • Discovery and Development of an Endothelin a Receptor-Selective Antagonist PD 156707

    Doherty, Annette M. (et al.)

    Pages 81-112

Buy this book

eBook $289.00
price for USA (gross)
  • ISBN 978-0-306-47384-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $369.00
price for USA
  • ISBN 978-0-306-45743-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $369.00
price for USA
  • ISBN 978-1-4419-3288-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Integration of Pharmaceutical Discovery and Development
Book Subtitle
Case Histories
Editors
  • Ronald T. Borchardt
  • Roger M. Freidinger
  • Tomi K. Sawyer
  • Philip L. Smith
Series Title
Pharmaceutical Biotechnology
Series Volume
11
Copyright
1998
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-0-306-47384-5
DOI
10.1007/b114429
Hardcover ISBN
978-0-306-45743-2
Softcover ISBN
978-1-4419-3288-4
Series ISSN
1078-0467
Edition Number
1
Number of Pages
XXIX, 610
Number of Illustrations and Tables
30 b/w illustrations, 1 illustrations in colour
Topics