Advances in Experimental Medicine and Biology

Mechanisms of Lymphocyte Activation and Immune Regulation VI

Cell Cycle and Programmed Cell Death in the Immune System

Editors: Gupta, Sudhir, Cohen, J. John (Eds.)

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About this book

Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Reviews

`This book is a valuable addition to the literature.'
Quarterly Review of Biology, March 1998

Table of contents (25 chapters)

  • Apoptosis/Programmed Cell Death

    Gupta, Sudhir

    Pages 1-9

  • Apoptosis and Its Regulation

    Cohen, J. John

    Pages 11-20

  • Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages

    Schlegel, Robert A. (et al.)

    Pages 21-28

  • Cytotoxic Lymphocyte Killing Enters the Ice Age

    Martin, Seamus J. (et al.)

    Pages 29-37

  • Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231

    Chmura, Steven J. (et al.)

    Pages 39-55

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4899-0274-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-306-45483-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-0276-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Lymphocyte Activation and Immune Regulation VI
Book Subtitle
Cell Cycle and Programmed Cell Death in the Immune System
Editors
  • Sudhir Gupta
  • J. John Cohen
Series Title
Advances in Experimental Medicine and Biology
Series Volume
406
Copyright
1996
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-0274-0
DOI
10.1007/978-1-4899-0274-0
Hardcover ISBN
978-0-306-45483-7
Softcover ISBN
978-1-4899-0276-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 270
Topics