Photobiology in Medicine

1. Front Matter

   Pages i-x

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2. Reactive Intermediates in Biology and Medicine

   1. Photophysical Techniques used in Photobiology and Photomedicine

      • Robert W. Redmond

      Pages 1-28

   2. Reactive Oxygen Species

      • Santiago Nonell

      Pages 29-50

   3. Biological Antioxidant and Defence/Repair Systems

      • Johan W. M. Lagerberg, Monique H. Rasch, Tom M. A. R. Dubbelman

      Pages 51-60

3. Photoreactions of Biological and Medical Importance

   1. Photosensitizers

      • Tom M. A. R. Dubbelman, John D. Spikes

      Pages 61-70

   2. Photoaddition by Furocoumarins

      • Dietrich Averbeck

      Pages 71-98

   3. Photopigmentation

      • Patrick A. Riley

      Pages 99-112

4. Damaging Effects of Light

   1. Systemic Effects from Phototoxic Drugs

      • Gerard M. J. Beijersbergen van Henegouwen

      Pages 113-124

   2. Phototoxicity of the Eye

      • Tadeusz Sarna, Małgorzata Różanowska

      Pages 125-141

5. Photomedicine

   1. Photoactivation of the Human Immunodeficiency Virus Type 1 Involves Complex Signaling Pathways

      • Jacques Piette, Sylvie Legrand-Poels

      Pages 143-160

   2. General Aspects of UV-Irradiation on the Immune System

      • Monique Hurks, Johan Garssen, Henk van Loveren, Bert-Jan Vermeer

      Pages 161-175

   3. Photodynamic Therapy of Cancers

      • Marie Thérèse Foultier, Véronique Vonarx-Coinsman, Laurent Morlet, Léonor Xavier de Brito, Nelly Robillard, Thierry Patrice

      Pages 177-186

6. Back Matter

   Pages 187-190

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Man has recognised an association of light with life and medicine for over 3000 years. Today the major challenges to this topic include the elucidation of photochemical reactions involved in photobiology at the molecular level. This includes the use of a variety of modem probing techniques that directly measures the reactivity of excited states and free radicals involved in biological reactions. This text-book is based on such an approach and has arisen from some of the lectures delivered at the NATO ASI held at Hotel Capo Caccia near the Centre for Advanced Research in Photobiology (CARP) in Sardegia, Italy. The ASI took place from 30 September -13 October 1993 and involved a total membership of 90. The book, like the NATO ASI itself, is divided into four themes starting with fundamental aspects and ending with complex medically related systems. Thus Theme 1 covers aspects of the underlying photophysics and photochemistry with particular emphasis on modem experimental techniques to study molecular mechanisms of biological processes. Theme 2 applies many of these fundamental studies to the chemical reactions of most relevance to photobiology and photomedicine such as photo-addition, -isomerization, -sensitization and -pigmentation. The third and fourth Themes deal with the deleterious and therapeutic aspects of light with particular emphasis on the use of Photo-Dynamic Therapy (PDT) to treat cancer and on viral and micro bioi infections.

• Activation
• Isomer
• antioxidant
• biological
• biology
• cancer
• experiment
• immunodeficiency
• medicine
• molecular mechanisms
• oxygen
• photochemistry
• physics
• therapy
• toxicity

• University of Padova, Padova, Italy

  Giulio Jori

• The Royal Military College of Canada, Kingston, Canada

  Roy H. Pottier

• Bowling Green State University, Bowling Green, USA

  Michael A. J. Rodgers

• Keele University, Keele, Staffordshire, England

  T. George Truscott

Policies and ethics