Advances in Experimental Medicine and Biology

Mechanisms of Lymphocyte Activation and Immune Regulation V

Molecular Basis of Signal Transduction

Editors: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R. (Eds.)

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About this book

Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.

Table of contents (26 chapters)

  • Signaling and Internalisation Function of the B Cell Antigen Receptor Complex

    Flaswinkel, Heinrich (et al.)

    Pages 1-8

  • Mechanism of B Cell Antigen Receptor Function: Transmembrane Signaling and Triggering of Apoptosis

    DeFranco, Anthony L. (et al.)

    Pages 9-22

  • B-Cell Activation by Wild Type and Mutant Ig-β Cytoplasmic Domains

    Taddie, John A. (et al.)

    Pages 23-34

  • Accessory Molecules that Influence Signaling Through B Lymphocyte Antigen Receptors

    Clark, Edward A. (et al.)

    Pages 35-43

  • Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3-ζ Chain

    Wegener, Anne-Marie K. (et al.)

    Pages 45-51

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-1-4899-0987-9
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-0-306-44897-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-1-4899-0989-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Lymphocyte Activation and Immune Regulation V
Book Subtitle
Molecular Basis of Signal Transduction
Editors
  • Sudhir Gupta
  • William E. Paul
  • Anthony DeFranco
  • Roger Perlmutter
Series Title
Advances in Experimental Medicine and Biology
Series Volume
365
Copyright
1994
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4899-0987-9
DOI
10.1007/978-1-4899-0987-9
Hardcover ISBN
978-0-306-44897-3
Softcover ISBN
978-1-4899-0989-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 264
Topics