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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

  • Book
  • © 1989

Overview

Editors:
  1. Derek LeRoith

    1. National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Mohan K. Raizada

    1. University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (41 chapters)

  1. Front Matter

    Pages N2-xii
    Download chapter PDF

  2. General Aspects of Insulin-Like Growth Factor Physiology

    1. Somatomedins: A New Look at Old Questions

      • William H. Daughaday
      Pages 1-4

    2. Autocrine and Paracrine Effects of the Somatomedins/Insulin-Like Growth Factors

      • Judson J. Van Wyk, P. Kay Lund
      Pages 5-23

    3. Role of IGFs in Growth Hormone Homeostasis

      • Michael Berelowitz
      Pages 25-37

    4. Interaction of IGF with the Hypothalamus and Pituitary

      • Ron G. Rosenfeld, Ian Ocrant, Karen L. Valentino, Andrew R. Hoffman
      Pages 39-56

    5. Feedback Regulation of Growth Hormone Gene Expression by Insulin-like Growth Factor I

      • Diane Prager, Shlomo Melmed, James Fagin
      Pages 57-71

    6. Growth Hormone and IGF Abnormalities of the African Pygmy

      • Thomas J. Merimee
      Pages 73-80

    7. Somatomedin Inhibitors

      • L. S. Phillips, S. Goldstein, J. D. Klein
      Pages 81-95

  3. Molecular Biology of Insulin-Like Growth Factors

    1. The Structure and Expression of the Human Insulin-Like Growth Factor Genes

      • Pieternella Holthuizen
      Pages 97-105

    2. Transcriptional Diversity in Rat Insulin-Like Growth Factor I Gene Expression

      • Charles T. Roberts Jr., William L. Lowe Jr., Derek LeRoith
      Pages 107-116

    3. Physiological Regulation of Insulin-Like Growth Factor Expression

      • P. Rotwein, D. DeVol, P. Lajara, P. Bechtel, M. Hammerman
      Pages 117-124

    4. Dietary and Hormonal Factors Affecting the mRNA Level of IGF-I in Rat Liver in vivo and in Primary Cultures of Rat Hepatocytes

      • Hisanori Kato, Yutaka Miura, Asako Okoshi, Tsutomu Umezawa, Shin-Ichiro Takahashi, Tadashi Noguchi
      Pages 125-128

    5. Expression of IGF-I in Liver

      • Thomas R. Johnson, Joseph Ilan
      Pages 129-139

    6. Ovarian Insulin-Like Growth Factor I: Basic Concepts Leading to Potential Clinical Outlets

      • Eli Y. Adashi, Carol E. Resnick, Eleuterio R. Hernandez, Marjorie E. Svoboda, Judson J. Van Wyk
      Pages 141-151

    7. Regulation of Insulin-Like Growth Factor-1 Gene Expression by Estrogen

      • Liam J. Murphy, Henry G. Friesen
      Pages 153-168

    8. Regulation of IGF-II Gene Expression in Human Adrenals, Gonads and Placenta

      • Raimo Voutilainen
      Pages 169-178

    9. Expression of Insulin-Like Growth Factors by the Human Placenta

      • Keith D. Boehm, Michael F. Kelley, Judith Ilan
      Pages 179-193

    10. IGFs in Pregnancy: Developmental Expression in Uterus and Mammary Gland and Paracrine Actions during Embryonic and Neonatal Growth

      • Frank A. Simmen, Rosalia C. M. Simmen, L. Roxanne Letcher, Douglas A. Schober, Yong Ko
      Pages 195-208

    11. Hormonal Feedback Regulation of Brain IGF-I and IGF-II Gene Expression

      • Teresa L. Wood, Michael Berelowitz, Jeffrey F. McKelvy
      Pages 209-217

    12. Expression of the IGF-II Gene in Brain and Muscle

      • Kenneth M. Rosen, Bruce M. Wentworth, Edward D. Lamperti, Stanislaus Kinota, Richard O’Brien, Nadia Rosenthal et al.
      Pages 219-229
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Keywords

About this book

An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.

Editors and Affiliations

  • National Institutes of Health, Bethesda, USA

    Derek LeRoith

  • University of Florida, Gainesville, USA

    Mohan K. Raizada

Bibliographic Information

  • Book Title: Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

  • Editors: Derek LeRoith, Mohan K. Raizada

  • DOI: https://doi.org/10.1007/978-1-4684-5685-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4684-5687-5Published: 18 July 2013

  • eBook ISBN: 978-1-4684-5685-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 511

  • Number of Illustrations: 167 b/w illustrations

  • Topics: Human Physiology

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