Nato Science Series A:

Leishmaniasis: The Current Status and New Strategies for Control

Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987

Editors: Hart, D.T. (Ed.)

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About this book

V Pentostam, an uncharacterized complex of Sb and carbohydrate derived from gluconic acid, is concentrated by Leishmania amastigotes via protein binding. Biochemical consequences of the interaction of amastigotes with Pentostam are inhibition of parasite bioenergetics and inhibition of ATP synthesis. REFERENCES 1. J.C. Mottram and G.H. Coombs. Enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicqls. Exper. Parasitol. 59:151 (1985). 125 2. S.L. Croft, K.D. Neame and C.A. Homewood. Accumulation of [ Sb] sodium stibogluconate by Leishmania mexicana amazonensis and Leishmania donovani in vitro. Compo Biochem. Physiol. 68c:95 (1981). 3. J.D. Berman, J.V. Gallalee, and B.D. Hansen. Leishmania mexicana: uptake of sodium stibogluconate (Pentostam) and pentamidine by parasite and macrophages. Exper. Parasitol. 64:127 (1987). 4. J.D. Berman, D. Waddell and B.D. Hanson. Biochemical meChanisms of the antileishmanial activity of sodium stibogluconate. Antimicrobial Agents Chemotherapy. 27:916 (1985). 5. J.D. Berman, J.V. Gallalee, and J.M. Best. Sodium stibogluconate (Pentostam) inhibition of glucose catabolism via the glycolytic pathway, and fatty acid B-oxidation in Leishmania mexicana amastigotes. Biochem. Pharmacol. 36:197 (1987). 6. D.T. Hart and G.H. Coombs. Leishmania mexicana: Energy metabolism of amastigotes and promastigotes. Exper. Parasitol. 54:397 (1982). 478 EFFECTS OF SINEFUNGIN ON CELLULAR AND BIOCHEMICAL EVENTS IN PROMASTIGOTES OF LEISHMANIA d. donovani Fran~oise Lawrence, and MaIka Robert-Cero Institut de Chimie des Substances Naturelles C.N.R.S.

Table of contents (6 chapter)

  • Reservoirs of Visceral Leishmaniasis

    P. Abranches

    Pages 61-70

    Buy Chapter $29.95
  • The Distribution and Aetiology of Diffuse Cutaneous Leishmaniasis in the New World

    Bryce C. Walton, Oscar Velasco

    Pages 149-157

    Buy Chapter $29.95
  • Why Measure the Vectorial Capacity of Sandflies?

    Christopher Dye

    Pages 245-251

    Buy Chapter $29.95
  • A Simple, Highly Repetitive Sequence in the Leishmania Genome

    John Ellis, Julian Crampton

    Pages 589-596

    Buy Chapter $29.95
  • Structure Function Studies on Leishmania Surface Membrane Proteins

    Robert W. Olafson, Raymond A. Dwek, Thomas W. Rademacher, Kwang-Poo Chang, Michael A. J. Ferguson

    Pages 619-625

    Buy Chapter $29.95
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Buy this book

eBook $449.00 net
( price for USA )
  • ISBN 978-1-4613-1575-9
  • digitally watermarked, no DRM
  • included format: PDF
  • eBooks can be used on all Reading Devices
Hardcover $569.00 net
( price for USA )
  • ISBN 978-0-306-43146-3
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days
Softcover $569.00 net
( price for USA )
  • ISBN 978-1-4612-8862-6
  • free shipping for individuals worldwide
  • usually dispatched within 3 to 5 business days

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Bibliographic Information

Bibliographic Information
Book Title
Leishmaniasis: The Current Status and New Strategies for Control
Book Subtitle
Proceedings of the NATO Advanced Study Institute, Zakynthos (Greece), 1987
Series Title
Nato Science Series A:
Series Volume
11
Copyright
1989
Publisher
Springer US
Copyright Holder
Springer-Verlag US
eBook ISBN
978-1-4613-1575-9
DOI
10.1007/978-1-4613-1575-9
Hardcover ISBN
978-0-306-43146-3
Softcover ISBN
978-1-4612-8862-6
Edition Number
1
Topics