Series of the Centro De Estudios Científicos

Ionic Channels in Cells and Model Systems

Editors: Latorre, Ramón (Ed.)

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About this book

This book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984. It is intended as a tutorial guide on the properties, function, modulation, and reconstitution of ionic channels, and it should be accessible to graduate students taking their first steps in this field. In the presentation there has been a deliberate emphasis on the spe­ cific methodologies used toward the understanding of the workings and function of channels. Thus, in the first section, we learn to "read" single­ channel records: how to interpret them in the theoretical frame of kinetic models, which information can be extracted from gating currents in re­ lation to the closing and opening processes, and how ion transport through an open channel can be explained in terms of fluctuating energy barriers. The importance of assessing unequivocally the origin and purity of mem­ brane preparations and the use of membrane vesicles and optical tech­ niques in the stUGY of ionic channels are also discussed in this section. The patch-clamp technique has made it possible to study ion channels in a variety of different cells and tissues not amenable to more conven­ tional electrophysiological methods. The second section, therefore, deals with the use of this technique in the characterization of ionic channels in different types of cells, ranging from plant protoplasts to photoreceptors.

Table of contents (27 chapters)

  • Introduction

    Latorre, Ramon

    Pages 1-2

  • Kinetic Models and Channel Fluctuations

    Alvarez, Osvaldo

    Pages 5-15

  • Single-Channel Currents and Postsynaptic Drug Actions

    Lecar, Harold

    Pages 17-36

  • Voltage-Dependent Gating

    Bezanilla, Francisco

    Pages 37-52

  • Characterizing the Electrical Behavior of an Open Channel via the Energy Profile for Ion Permeation

    Eisenman, George (et al.)

    Pages 53-87

Buy this book

eBook $74.99
price for USA (gross)
  • ISBN 978-1-4684-5077-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $99.00
price for USA
  • ISBN 978-0-306-42194-5
  • Free shipping for individuals worldwide
  • This title is currently reprinting. You can pre-order your copy now.
Softcover $99.00
price for USA
  • ISBN 978-1-4684-5079-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Ionic Channels in Cells and Model Systems
Editors
  • Ramón Latorre
Series Title
Series of the Centro De Estudios Científicos
Copyright
1986
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5077-4
DOI
10.1007/978-1-4684-5077-4
Hardcover ISBN
978-0-306-42194-5
Softcover ISBN
978-1-4684-5079-8
Series ISSN
1571-571X
Edition Number
1
Number of Pages
XXIII, 437
Number of Illustrations and Tables
37 b/w illustrations
Topics