Overview
Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases
Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors
Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry
Includes supplementary material: sn.pub/extras
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (30 chapters)
-
Front Matter
-
Role of Proteases in the Development of Cancer
-
Front Matter
-
-
Role of Proteases in Different Diseases
-
Front Matter
-
Keywords
About this book
Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Editors and Affiliations
About the editors
He received a Fulbright visiting fellowship to pursue research at the Department of Medicine, The Johns Hopkins University, USA from 1987 to 1989, and at the Pulmonary Division, University of Utah Medical School and New York Medical College, New York, USA from 1989 to mid-1990. He joined the University of Kalyani as a Reader in Biochemistry in 1998. Dr. Chakraborti is actively involved in research and has more than 100 publications in prominent journals to his credit. He has also contributed chapters to books published by Springer and Elsevier. He has edited four books with Springer, namely: Proteases in Health and Disease; Role of Proteases in Cellular Dysfunction; Regulation of Membrane Na/K-ATPase; and Regulation of Ca2+ ATPases, V-ATPases and F-ATPases.
Dr. Naranjan S. Dhalla is Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 45 years.
Bibliographic Information
Book Title: Pathophysiological Aspects of Proteases
Editors: Sajal Chakraborti, Naranjan S. Dhalla
DOI: https://doi.org/10.1007/978-981-10-6141-7
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-6140-0Published: 04 December 2017
Softcover ISBN: 978-981-13-5579-0Published: 11 December 2018
eBook ISBN: 978-981-10-6141-7Published: 15 November 2017
Edition Number: 1
Number of Pages: XV, 671
Number of Illustrations: 17 b/w illustrations, 71 illustrations in colour
Topics: Human Physiology, Molecular Medicine, Pharmaceutical Sciences/Technology, Cancer Research