IgG4-Related Sclerosing Cholangitis

1. Front Matter

   Pages i-viii

   PDF

2. Overview

   • Takahiro Nakazawa, Shuya Simizu, Tadashi Toyohara, Hiromichi Araki, Katumi Hayashi

   Pages 1-7

3. Epidemiology

   • Atsushi Tanaka

   Pages 9-11

4. Pathophysiology

   • Yoh Zen

   Pages 13-22

5. Pathology

   • Kenji Notohara

   Pages 23-32

6. Clinical Features

   • Jong Kyun Lee

   Pages 33-37

7. Serum IgG4

   • Tetsuya Ito, Takayuki Watanabe, Takashi Muraki, Shigeyuki Kawa

   Pages 39-44

8. Diagnostic Criteria

   • Hirotaka Ohara, Itaru Naitoh, Kazuki Hayashi, Katsuyuki Miyabe, Takahiro Nakazawa

   Pages 45-50

9. Imaging: US and CT

   • Hisato Igarashi, Testuhide Ito, Kosei Ishigami, Masayuki Hijioka, Hirotaka Ohara

   Pages 51-55

10. Imaging: MRI with MRCP

    • Jae Ho Byun

    Pages 57-61

11. Imaging: ERCP

    • Atsushi Kanno, Atsushi Masamune, Tooru Shimosegawa

    Pages 63-70

12. Imaging: EUS and IDUS

    • Itaru Naitoh, Takahiro Nakazawa, Hirotaka Ohara, Takashi Joh

    Pages 71-77

13. Differential Diagnosis from Primary Sclerosing Cholangitis

    • Sung-Hoon Moon, Myung-Hwan Kim

    Pages 79-85

14. Differential Diagnosis Between Proximal-Type IgG4-Related Sclerosing Cholangitis and Hilar Cholangiocarcinoma

    • Kensuke Kubota, Akito Iwasaki, Takamitsu Sato, Kunihiro Hosono

    Pages 87-94

15. Tissue Acquisition for Histologic Diagnosis

    • Ji Kon Ryu

    Pages 95-97

16. Other Organ Involvements

    • Satomi Koizumi, Terumi Kamisawa, Sawako Kuruma, Kazuro Chiba, Masataka Kikuyama

    Pages 99-104

17. Treatment: Steroids

    • Hee Seung Lee, Seungmin Bang

    Pages 105-107

18. Treatment: Immunomodulatory Drugs

    • Kazushige Uchida, Kazuichi Okazaki

    Pages 109-112

19. Treatment: Rituximab

    • Shounak Majumder, Mark D. Topazian

    Pages 113-118

20. Prognosis

    • Takeshi Kuwada, Masahiro Shiokawa, Teruko Tomono, Norimitsu Uza, Yuzo Kodama

    Pages 119-124

This book aims to raise awareness of IgG4-related sclerosing cholangitis among practicing physicians and to equip readers with a sound understanding of the principles of diagnosis and treatment. Clinical, serological, and histopathological features are clearly described and imaging appearances on all relevant modalities are illustrated, covering the bile duct and other involved organs. Differential diagnosis from other diseases, including primary sclerosing cholangitis and cholangiocarcinoma, is precisely explained. Information is then presented on all significant current and emerging therapeutic strategies, including steroids, immunosuppressive drugs, and rituximab. Finally, attention is drawn to significant prognostic features. While IgG4-related sclerosing cholangitis is now a widely acknowledged condition, most practitioners are still liable to misdiagnose it owing to a lack of familiarity with its presenting features. This book should help to rectify the situation and will be an asset for all who may encounter the disease in clinical practice.

• IgG4
• Primary sclerosing cholangitis
• Cholangiocarcinoma
• Steroid
• Endoscopic retrograde cholangiopancreatography

• Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan

  Terumi Kamisawa

• Department of Internal Medicine, ASAN Medical Center, Seoul, Korea (Republic of)

  Myung-Hwan Kim

Terumi Kamisawa, MD, PhD, AGAF, is a gastroenterologist who specializes in pancreatobiliary disease. He became deputy director of Tokyo Metropolitan Komagome Hospital in 2015. Dr. Kamisawa gained a Master’s degree and PhD from Hirosaki University School of Medicine, Aomori, Japan, in 1982 and 1995, respectively. He became an executive board member of the Japan Biliary Association in 2011 and of the Japan Pancreas Society in 2012. Since 2007 he has been an associate editor of Pancreas and Journal of the Pancreas. He is an editorial board member of the Journal of Gastroenterology, the Journal of Hepatobiliary Pancreatic Sciences, and Gut and Liver.
Myung-Hwan Kim, MD, PhD, is a gastroenterologist with a special interest in pancreatobiliary disease. He is a professor at University of Ulsan College of Medicine and Director of the Pancreatobiliary Center at the Asan Medical Center. He is a former president of the Korean Pancreatobiliary Association and also of the Korean Society of Gastrointestinal Endoscopy. He is now a Council member of both the International Association of Pancreatology (IAP) and the Asian Oceanic Pancreatic Association (AOPA).

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