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New Horizons of Process Chemistry

Scalable Reactions and Technologies

  • Book
  • © 2017

Overview

Editors:
  1. Kiyoshi Tomioka

    1. Doshisha Women's College of Liberal Arts , Kyotanabe, Japan

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  2. Takayuki Shioiri

    1. Meijo University, Nagoya, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Hironao Sajiki

    1. Gifu Pharmaceutical University , Gifu, Japan

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  • Is highly relevant not only to process chemists but also to synthetic and medicinal chemists
  • Includes actual examples of industrial process chemistry
  • Provides abundant useful information for practical methodologies and devices geared to process chemistry
  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Recent Advances in Rare Earth Metal Asymmetric Catalysis Toward Practical Synthesis of Therapeutics

    • Naoya Kumagai, Masakatsu Shibasaki
    Pages 1-10

  3. Metal Catalyzed Synthetic Reactions via Aerobic Oxidation as a Key Step

    • Mitsuru Shindo, Kenji Matsumoto
    Pages 11-27

  4. Heterogeneous Platinum Metal Catalyzed Deuterium Generation and Labeling Methods Using Hydrogen Gas and Deuterium Oxide as Key Reagents

    • Hironao Sajiki
    Pages 29-40

  5. Pd on Spherical Carbon (Pd/SC)-Catalyzed Chemoselective Hydrogenation

    • Hiroyoshi Esaki
    Pages 41-50

  6. Environment-Friendly Iron-Catalyzed Reactions

    • Yoshinari Sawama
    Pages 51-63

  7. Tetranuclear Zinc Cluster-Catalyzed Transesterification

    • Takashi Ohshima
    Pages 65-87

  8. Vinyl Ruthenium Carbenes: Valuable Intermediates in Catalysis

    • Damián Padín, Jesús A. Varela, Carlos Saá
    Pages 89-102

  9. Radical-Based Late Stage C–H Functionalization of Heteroaromatics in Drug Discovery

    • Yuta Fujiwara, Phil S. Baran
    Pages 103-120

  10. Magnetic Nanoparticle-Supported Iodoarene Oxidative Catalysts and Its Application to Phenol Oxidation

    • Hisanori Nambu, Ikumi Shimokawa, Tomoya Fujiwara, Takayuki Yakura
    Pages 121-129

  11. Recent Development of Diphenyl Phosphorazidate (DPPA) as a Synthetic Reagent

    • Takayuki Shioiri
    Pages 131-145

  12. Methylenation Reaction of Carbonyl Compounds Using Julia-Kocienski Reagents

    • Kaori Ando
    Pages 147-162

  13. Development of Shelf-Stable Reagents for Electrophilic Trifluoromethylthiolation Reaction

    • Zhongyan Huang, Norio Shibata
    Pages 163-178

  14. Practical and Environmentally Friendly Transformation of Tetrahydrofuran-2-Methanols to γ-Lactones via Oxidative Cleavage

    • Tomoya Fujiwara, Yuto Horiuchi, Akihiro Yamada, Hisanori Nambu, Takayuki Yakura
    Pages 179-190

  15. Five Step Asymmetric Total Synthesis of β-Lycorane Employing Chiral Diether Ligand-Controlled Conjugate Addition-Michael Reaction Cascade

    • Kiyoshi Tomioka
    Pages 191-200

  16. Concise Synthesis of Peptide Analogs Using a Fluorous-Fmoc Protection Strategy

    • Masato Matsugi
    Pages 201-215

  17. A Challenging Synthesis of the Highly Functionalized Echinocandin ASP9726: A Successor of Micafungin—How Can We Achieve the Large-Scale Synthesis?

    • Shinya Yoshida, Joji Hayashida, Yasuhiro Morinaga, Shoji Mizobata, Akihiro Okada, Kazumi Kawai et al.
    Pages 217-227

  18. The Role of Silyl Protecting Group for the Synthesis of Procyanidins and Their Derivatives

    • Noriyuki Nakajima, Akiko Saito
    Pages 229-236

  19. Chemical Modification of the 3′-Dangling End of Small Interfering RNAs Such as siRNAs and miRNAs: The Development of miRNA Replacement Therapy

    • Yukio Kitade, Takashi Mori, Yukihiro Akao
    Pages 237-249

  20. Antiviral Agents Towards Chikungunya Virus: Structures, Syntheses, and Isolation from Natural Sources

    • Jih Ru Hwu, Tapan K. Pradhan, Shwu-Chen Tsay, Mohit Kapoor, Sergey O. Bachurin, Oleg A. Raevsky et al.
    Pages 251-274
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Keywords

About this book

The methodologies and technologies adaptable to process chemistry are the focus of this unique book, as new catalysts, reactions, and methods for the synthesis of functional materials are dealt with in depth for the first time. Those materials take in pharmaceuticals, agrochemicals, functional materials, chemical raw materials, and other substances in the field of process chemistry including green chemistry. Process chemistry underpins the competitiveness of chemical and pharmaceutical industries, but its stagnation is estimated to cause industrial depression and excessive loss. For that reason, chemists focus on process chemistry consistently so that the development of novel and efficient new reactions and technologies provides an essential stimulus. In addition, this volume describes the important development of selected new synthetic devices for process development and the process design for a larger scale, thus furnishing a valuable source for all who are engaged in process chemistry. 

Editors and Affiliations

  • Doshisha Women's College of Liberal Arts , Kyotanabe, Japan

    Kiyoshi Tomioka

  • Meijo University, Nagoya, Japan

    Takayuki Shioiri

  • Gifu Pharmaceutical University , Gifu, Japan

    Hironao Sajiki

About the editors



Kiyoshi Tomioka
President of the Japanese Society for Process Chemistry 
Professor of Doshisha Women's College of Liberal Arts
Emeritus Professor of Kyoto University 
The Pharmaceutical Society of Japan Award (2003)
The Pharmaceutical Society of Japan Award for Young Scientists (1984)
Vice President of Pharmaceutical Society of Japan (2011–2013)
Japan Regional Executive Editor of Tetrahedron (2008-)



Takayuki Shioiri
Honorary President of the Japanese Society for Process Chemistry,
Emeritus Professor of Nagoya City University
The Pharmaceutical Society of Japan Award (1993)
Japanese Peptide Society Award (1999)
Japan Regional Executive Editor of Tetrahedron (1990-2007) 
President of the Japanese Peptide Society (2000–2002)


Hironao Sajiki
Vice President of the Japanese Society for Process Chemistry
Professor of Gifu Pharmaceutical University 
The Pharmaceutical Society of Japan Award for Divisional Scientific Contributions Award (2012)
The Society of Synthetic Organic Chemistry, Japan Nissan Chemical Industries Award for Novel Reaction& Method (2012) 

Bibliographic Information

  • Book Title: New Horizons of Process Chemistry

  • Book Subtitle: Scalable Reactions and Technologies

  • Editors: Kiyoshi Tomioka, Takayuki Shioiri, Hironao Sajiki

  • DOI: https://doi.org/10.1007/978-981-10-3421-3

  • Publisher: Springer Singapore

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2017

  • Hardcover ISBN: 978-981-10-3420-6Published: 27 March 2017

  • Softcover ISBN: 978-981-10-9869-7Published: 09 May 2018

  • eBook ISBN: 978-981-10-3421-3Published: 17 March 2017

  • Edition Number: 1

  • Number of Pages: IX, 285

  • Number of Illustrations: 150 b/w illustrations, 88 illustrations in colour

  • Topics: Industrial Chemistry/Chemical Engineering, Organic Chemistry, Pharmacy, Agriculture, Catalysis

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