Editors:
- First book focusing on immune cell metabolism
- Discussing the critical role of immune cell metabolism in regulating normal cell physiology, as well as immune cell functions in tumors
- Providing a cutting-edge and comprehensive overview of essential research on immune cell metabolism
- Written by experts in this field?
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1011)
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Table of contents (7 chapters)
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Front Matter
About this book
This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients.
The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders.
This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.
Editors and Affiliations
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Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University, Shanghai, China
Bin Li
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School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Fan Pan
About the editors
Dr. Bin Li is a distinguished professor at Shanghai Jiao Tong University, a Yu He Scholar and senior investigator at Shanghai Institute of Immunology and the Department of Immunology and Microbiology at Shanghai JiaoTong University School of Medicine, China. Research in Li’s laboratory mainly focuses on understanding molecular mechanisms underlying the functional stability, plasticity and balance of FOXP3+ Regulatory T cells (Treg) and RORgt+ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutic modulation, especially by compounds from Chinese Traditional Medicine. We expect that our original findings will be translational to the biomedical industry and be beneficial to human health.
Dr. Fan Pan is an associate professor of cancer immunology at the Department of Oncology & Bloomberg-Kimmel Institute (BKI) at Johns Hopkins University School of Medicine. His research interests concern the molecular mechanisms controlling the development, lineage stability and function of T cell subsets. By pursuing these research avenues, he is expanding upon multiple, newly appreciated aspects of Treg biology, immune regulation and metabolic pathways, and with these insights bringing about new immunotherapy strategies to combat cancer.
Bibliographic Information
Book Title: Immune Metabolism in Health and Tumor
Editors: Bin Li, Fan Pan
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-94-024-1170-6
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2017
Hardcover ISBN: 978-94-024-1168-3Published: 22 September 2017
Softcover ISBN: 978-94-024-1502-5Published: 15 August 2018
eBook ISBN: 978-94-024-1170-6Published: 05 September 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: V, 223
Number of Illustrations: 1 b/w illustrations, 23 illustrations in colour
Topics: Immunology, Posttranslational Modification, Medical Microbiology, Cancer Research