Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (6 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailability of drugs, is used to prevent upper gastrointestinal disorders. The author performed a clinical pharmacokinetic study in renal transplant patients to evaluate a potential interaction of MPA and pantoprazole. The bioavailability and the maximum concentration of MPA were determined with or without pantoprazole intake. An influence on the immunosuppressive effect was evaluated by measuring the target enzyme activity. Overall, no significant change in the bioavailability or the maximum concentration was found. Similar results were obtained for the target enzyme activity after pantoprazole intake with MPA. The results suggest that the interaction of pantoprazole with MPA does not compromise the immunosuppressive effect to a clinically meaningful extent.
Authors and Affiliations
About the author
Olesja Rissling studied pharmacy and works as a research associate at the Federal Joint Committee in the field of benefit assessment of pharmaceuticals.
Bibliographic Information
Book Title: Interaction of Mycophenolic Acid and Pantoprazole
Book Subtitle: A Pharmacokinetic Crossover Study
Authors: Olesja Rissling
DOI: https://doi.org/10.1007/978-3-658-19889-3
Publisher: Springer Spektrum Wiesbaden
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Fachmedien Wiesbaden GmbH 2017
Softcover ISBN: 978-3-658-19888-6Published: 23 November 2017
eBook ISBN: 978-3-658-19889-3Published: 01 November 2017
Edition Number: 1
Number of Pages: XXII, 162
Number of Illustrations: 13 b/w illustrations, 10 illustrations in colour