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Cellular and Molecular Approaches to Regeneration and Repair

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  • © 2018

Overview

Editors:
  1. Paul A. Lapchak

    1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, AHSP, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John H. Zhang

    1. Department of Physiology, Loma Linda University, Loma Linda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Stem cell therapy and molecular approaches
  • Covers the topic from lab work to clinical trial design
  • Contributions from some of the leading researchers in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-vii
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  2. Stem Cells

    1. Front Matter

      Pages 1-1
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    2. Stroke: Cytoprotection, Repair and Regeneration—The Continuum of Patient Care

      • Paul A. Lapchak
      Pages 3-20

    3. Interdisciplinary Advances Towards Understanding and Enhancing the Therapeutic Potential of Stem Cell-Based Therapies for Ischaemic Stroke

      • Pascal Gervois, Yörg Dillen, Tim Vangansewinkel, Petra Hilkens, Ronald B. Driesen, Greet Merckx et al.
      Pages 21-45

    4. Stem Cell Transplants in the Aged Stroke Brain: Microenvironment Factors

      • Aurel Popa-Wagner, Mario Di Napoli
      Pages 47-71

    5. Modulating Endogenous Adult Neural Stem Cells to Improve Regeneration in Stroke Brain

      • Fucheng Luo, Yu Luo
      Pages 73-99

    6. Mobilization of Endogenous Neural Stem Cells to Promote Regeneration After Stroke

      • Monika Rabenstein, Maria Adele Rueger
      Pages 101-112

    7. Transcriptional and Genomic Advances on the Pathophysiology of Stem Cell Repairment After Intracerebral Hemorrhage

      • Sheng Zhang, Yongjie Zhou, Yujie Chen
      Pages 113-127

    8. Modulation of Post-Stroke Plasticity and Regeneration by Stem Cell Therapy and Exogenic Factors

      • Lukas Andereggen, Raluca Reitmeir, Stefano Di Santo, Raphael Guzman, Hans R. Widmer, Serge Marbacher et al.
      Pages 129-152

    9. Stem Cell-Paved Biobridge: A Merger of Exogenous and Endogenous Stem Cells Toward Regenerative Medicine in Stroke

      • Hung Nguyen, M. Grant Liska, Marci G. Crowley, Cesario V. Borlongan
      Pages 153-180

    10. Bone-Marrow-Derived Cell Therapies in Stroke: Immunomodulatory Effects

      • Laith Maali, David C. Hess
      Pages 181-195

    11. The Combination of Stem Cell Factor (SCF) and Granulocyte-Colony Stimulating Factor (G-CSF) in Repairing the Brain Post-acute Stroke

      • Li-Ru Zhao, Suning Ping, Fei Hao
      Pages 197-215

    12. Mesenchymal Stromal Cell Therapy of Stroke

      • Yi Shen, Poornima Venkat, Michael Chopp, Jieli Chen
      Pages 217-237

    13. Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke

      • Qian Zhang, Yonghua Zhao
      Pages 239-257

    14. Gene Therapy for Cognitive Recovering After Ischemic Stroke

      • Johanna Gutierrez-Vargas, Rafael Posada-Duque, Gloria Patricia Cardona-Gómez
      Pages 259-280

    15. SB623 Preclinical and Clinical Trial Experience

      • Eric S. Sussman, Gary K. Steinberg
      Pages 281-292

    16. Preparing for Future Stem Cell Clinical Trials

      • Keith W. Muir
      Pages 293-307

  3. Exosomes-miRNA

    1. Front Matter

      Pages 309-309
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    2. Extra-Cellular Vesicles: A Promising Approach for Translating Cell-Based Therapy

      • Benjamin Buller, Michael Chopp, Zheng Gang Zhang
      Pages 311-324

    3. Exosome and MiRNA in Stroke

      • Ji Bihl, Jinju Wang, Xiaotang Ma, Yi Yang, Bin Zhao, Yanfang Chen
      Pages 325-361
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Keywords

About this book

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.

Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.

Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA.  Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. 

Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.  

Editors and Affiliations

  • Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, AHSP, Los Angeles, USA

    Paul A. Lapchak

  • Department of Physiology, Loma Linda University, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Cellular and Molecular Approaches to Regeneration and Repair

  • Editors: Paul A. Lapchak, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-3-319-66679-2

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-66678-5Published: 17 November 2017

  • Softcover ISBN: 978-3-319-88299-4Published: 29 August 2018

  • eBook ISBN: 978-3-319-66679-2Published: 04 November 2017

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: VII, 541

  • Number of Illustrations: 1 b/w illustrations, 45 illustrations in colour

  • Topics: Neurosciences, Neurology

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