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  • © 2018

Systems Biology

  • Inlcudes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1702)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-xvii
  2. An Integrative Approach Toward Biology, Organisms, and Cancer

    • Carlos Sonnenschein, Ana M. Soto
    Pages 15-26
  3. The Search for System’s Parameters

    • Alessandro Giuliani
    Pages 57-68
  4. Inverse Problems in Systems Biology: A Critical Review

    • Rodolfo Guzzi, Teresa Colombo, Paola Paci
    Pages 69-94
  5. Systems Biology Approach and Mathematical Modeling for Analyzing Phase-Space Switch During Epithelial-Mesenchymal Transition

    • Chiara Simeoni, Simona Dinicola, Alessandra Cucina, Corrado Mascia, Mariano Bizzarri
    Pages 95-123
  6. Parameters Estimation in Phase-Space Landscape Reconstruction of Cell Fate: A Systems Biology Approach

    • Sheyla Montero, Reynaldo Martin, Ricardo Mansilla, Germinal Cocho, José Manuel Nieto-Villar
    Pages 125-170
  7. Systems Biology Modeling of Nonlinear Cancer Dynamics

    • Christian Cherubini, Simonetta Filippi, Alessandro Loppini
    Pages 203-213
  8. Endogenous Molecular-Cellular Network Cancer Theory: A Systems Biology Approach

    • Gaowei Wang, Ruoshi Yuan, Xiaomei Zhu, Ping Ao
    Pages 215-245
  9. A Network-Based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression

    • Faiz M. Khan, Mehdi Sadeghi, Shailendra K. Gupta, Olaf Wolkenhauer
    Pages 247-276
  10. Metabolomics: Challenges and Opportunities in Systems Biology Studies

    • Luca Casadei, Mariacristina Valerio, Cesare Manetti
    Pages 327-336
  11. Systems Biology-Driven Hypotheses Tested In Vivo: The Need to Advancing Molecular Imaging Tools

    • Garima Verma, Alessandro Palombo, Mauro Grigioni, Morena La Monaca, Giuseppe D’Avenio
    Pages 337-359
  12. Back Matter

    Pages 361-364

About this book

This volume focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective behavior, metabolic, dynamic profiling, and quantitative morphological studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Systems Biology aims to ensure successful results in the further study of this vital field.

Editors and Affiliations

  • Department of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy

    Mariano Bizzarri

Bibliographic Information

  • Book Title: Systems Biology

  • Editors: Mariano Bizzarri

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7456-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2018

  • Hardcover ISBN: 978-1-4939-7455-9Published: 24 November 2017

  • Softcover ISBN: 978-1-4939-8491-6Published: 30 August 2018

  • eBook ISBN: 978-1-4939-7456-6Published: 07 November 2017

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XVII, 364

  • Number of Illustrations: 19 b/w illustrations, 83 illustrations in colour

  • Topics: Bioinformatics

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access