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Statistical Human Genetics

Methods and Protocols

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 1666)

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Table of contents (32 protocols)

  1. Front Matter

    Pages i-xii
  2. Statistical Genetic Terminology

    • Robert C. Elston, Jaya Satagopan, Shuying Sun
    Pages 1-9
  3. Identification of Genotype Errors

    • Jeffery O’Connell, Yin Yao
    Pages 11-23
  4. Identifying Cryptic Relationships

    • Lei Sun, Apostolos Dimitromanolakis, Wei-Min Chen
    Pages 45-60
  5. Estimating Allele Frequencies

    • Indra Adrianto, Courtney Montgomery
    Pages 61-81
  6. Testing Departure from Hardy-Weinberg Proportions

    • Jian Wang, Sanjay Shete
    Pages 83-115
  7. Estimating Disequilibrium Coefficients

    • Maren Vens, Andreas Ziegler
    Pages 117-132
  8. Detecting Familial Aggregation

    • Adam C. Naj, Terri H. Beaty
    Pages 133-169
  9. Estimating Heritability from Twin Studies

    • Katrina L. Grasby, Karin J. H. Verweij, Miriam A. Mosing, Brendan P. Zietsch, Sarah E. Medland
    Pages 171-194
  10. Correcting for Ascertainment

    • Warren Ewens, Robert C. Elston
    Pages 211-232
  11. Segregation Analysis Using the Unified Model

    • Xiangqing Sun
    Pages 233-256
  12. Design Considerations for Genetic Linkage and Association Studies

    • Jérémie Nsengimana, D. Timothy Bishop
    Pages 257-281
  13. Model-Based Linkage Analysis of a Quantitative Trait

    • Yeunjoo E. Song, Sunah Song, Audrey H. Schnell
    Pages 283-310
  14. Model-Based Linkage Analysis of a Binary Trait

    • Rita M. Cantor
    Pages 311-326
  15. Model-Free Linkage Analysis of a Quantitative Trait

    • Nathan J. Morris, Catherine M. Stein
    Pages 327-342
  16. Model-Free Linkage Analysis of a Binary Trait

    • Wei Xu, Jin Ma, Celia M. T. Greenwood, Andrew D. Paterson, Shelley B. Bull
    Pages 343-373
  17. Single Marker Association Analysis for Unrelated Samples

    • Gang Zheng, Ao Yuan, Qizhai Li, Joseph L. Gastwirth
    Pages 375-389
  18. Single Marker Family-Based Association Analysis Conditional on Parental Information

    • Ren-Hua Chung, Daniel D. Kinnamon, Eden R. Martin
    Pages 391-407

About this book

The aim of this volume is to make computer programs for analyzing human genetic data more easily accessible to the beginner.Statistical Human Genetics: Methods and Protocols, Second Edition provides updated and new chapters detailing genetic terms, analysis software, and how to interpret the program outputs. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, step-by-step instructions, and tips on troubleshooting and avoiding known pitfalls. 

The purpose of Statistical Human Genetics: Methods and Protocols, Second Edition is to ensure successful and meaningful results in the fast-growing field of genetic epidemiology.

Editors and Affiliations

  • Case Western Reserve University, Cleveland, USA

    Robert C. Elston

Bibliographic Information

  • Book Title: Statistical Human Genetics

  • Book Subtitle: Methods and Protocols

  • Editors: Robert C. Elston

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-7274-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media LLC 2017

  • Hardcover ISBN: 978-1-4939-7273-9Published: 04 October 2017

  • Softcover ISBN: 978-1-4939-8438-1Published: 14 August 2018

  • eBook ISBN: 978-1-4939-7274-6Published: 04 October 2017

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XII, 689

  • Number of Illustrations: 50 b/w illustrations, 64 illustrations in colour

  • Topics: Human Genetics

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 139.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access