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Statistics - Life Sciences, Medicine & Health | Statistics Applied to Clinical Trials

Statistics Applied to Clinical Trials

Cleophas, T.J., Cleophas, T.J., Zwinderman, A.H., Zwinderman, A.H., Cleophas, T.F., Cleophas, T.F., Cleophas, E.P.

3rd ed., XV, 366p.

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Content Level » Research

Keywords » Clinical Trials - Likelihood - Logistic Regression - Pharmaceutical medicine - Regression analysis - analysis of variance - clinical research - clinical trial - data analysis - evidence - based medicine - linear regression - research - statistics

Related subjects » Life Sciences, Medicine & Health - Statistics

Table of contents 

Foreword
Chapter 1: Hypotheses, Data, Stratification
Chapter 2: The Analysis of Efficacy Data
Chapter 3: The Analysis of Safety Data
Chapter 4: Log Likelihood Ratio Tests for Safety Data Analysis
Chapter 5: Equivalence Testing
Chapter 6: Statistical Power and Sample Size
Chapter 7: Interim Analyses
Chapter 8: Clinical Trials Are Often False Positive
Chapter 9: Multiple Statistical Inferences
Chapter 10: The Interpretation of the P-Values
Chapter 11: Research Data Closer to Expectation than Compatible with Random Sampling
Chapter 12: Statistical Tables for Testing Data Closer to Expectation than Compatible with Random Sampling
Chapter 13: Principles of Linear Regression
Chapter 14: Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism
Chapter 15: Curvilinear Regression
Chapter 16: Logistic and Cox Regression, Markow Models, Regression with Laplace Transformations
Chapter 17: Regression Modeling For Improved Precision
Chapter 18: Post-Hoc Analysis in Clinical Trials, A Case For Logistic Regression Analysis
Chapter 19: Confounding
Chapter 20: Interaction
Chapter 21: Meta-Analysis, Basic Approach
Chapter 22: Meta-Analysis, Review and Update of Methodologies
Chapter 23: Crossover Studies with Continuous Variables
Chapter 24: Crossover Studies with Binary Responses
Chapter 25: Cross-Over Trials Should Not Be Used To Test Treatments with Different Chemical Class
Chapter 26: Quality-Of-Life Assessments in Clinical Trials
Chapter 27: Statistics for the Analysis of Genetic Data
Chapter 28: Relationship among Statistical Distributions
Chapter 29: Testing Clinical Trials for Randomness
Chapter 30: Clinical Trials Do Not Use Random Samples Anymore
Chapter 31: Clinical Data Where Variability Is More Important than Averages
Chapter 32: Testing Reproducibility
Chapter 33: Validating Qualitative Diagnostic Tests
Chapter 34: Uncertainty of Qualitative Diagnostic Tests
Chapter 35: Meta-Analyses of Qualitative Diagnostic Tests
Chapter 36: Validating Quantitative Diagnostic Tests
Chapter 37: Summary of Validation Procedures for Diagnostic Tests
Chapter 38: Validating Surrogate Endpoints of Clinical Trials
Chapter 39: Methods for Repeated Measures Analysis
Chapter 40: Advanced Analysis Of Variance, Random Effects and Mixed Effects Models
Chapter 41: Monte Carlo Methods for Data Analysis
Chapter 42: Physicians’ Daily Life and the Scientific Method
Chapter 43: Superiority-Testing
Chapter 44: Trend-Testing
Chapter 45: Odds Ratios and Multiple Regression, Why and How to Use Them
Chapter 46: Statistics Is No "Bloodless" Algebra
Chapter 47: Bias Due to Conflicts of Interests, Some Guidelines
Appendix
Index

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